Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006416785> ?p ?o ?g. }
- W2006416785 endingPage "e7364" @default.
- W2006416785 startingPage "e7364" @default.
- W2006416785 abstract "Background Although it is a crucial cellular process required for both normal development and to face stress conditions, the control of programmed cell death in plants is not fully understood. We previously reported the isolation of ATXR5 and ATXR6, two PCNA-binding proteins that could be involved in the regulation of cell cycle or cell death. A yeast two-hybrid screen using ATXR5 as bait captured AtIPS1, an enzyme which catalyses the committed step of myo-inositol (MI) biosynthesis. atips1 mutants form spontaneous lesions on leaves, raising the possibility that MI metabolism may play a role in the control of PCD in plants. In this work, we have characterised atips1 mutants to gain insight regarding the role of MI in PCD regulation. Methodology/Principal Findings - lesion formation in atips1 mutants depends of light intensity, is due to PCD as evidenced by TUNEL labelling of nuclei, and is regulated by phytohormones such as salicylic acid - MI and galactinol are the only metabolites whose accumulation is significantly reduced in the mutant, and supplementation of the mutant with these compounds is sufficient to prevent PCD - the transcriptome profile of the mutant is extremely similar to that of lesion mimic mutants such as cpr5, or wild-type plants infected with pathogens. Conclusion/Significance Taken together, our results provide strong evidence for the role of MI or MI derivatives in the regulation of PCD. Interestingly, there are three isoforms of IPS in Arabidopsis, but AtIPS1 is the only one harbouring a nuclear localisation sequence, suggesting that nuclear pools of MI may play a specific role in PCD regulation and opening new research prospects regarding the role of MI in the prevention of tumorigenesis. Nevertheless, the significance of the interaction between AtIPS1 and ATXR5 remains to be established." @default.
- W2006416785 created "2016-06-24" @default.
- W2006416785 creator A5008492856 @default.
- W2006416785 creator A5011667102 @default.
- W2006416785 creator A5019491950 @default.
- W2006416785 creator A5020004955 @default.
- W2006416785 creator A5021116127 @default.
- W2006416785 creator A5040891053 @default.
- W2006416785 creator A5064491863 @default.
- W2006416785 creator A5069498194 @default.
- W2006416785 creator A5069881188 @default.
- W2006416785 creator A5072554892 @default.
- W2006416785 creator A5081577800 @default.
- W2006416785 creator A5089322890 @default.
- W2006416785 date "2009-10-08" @default.
- W2006416785 modified "2023-09-29" @default.
- W2006416785 title "Crosstalks between Myo-Inositol Metabolism, Programmed Cell Death and Basal Immunity in Arabidopsis" @default.
- W2006416785 cites W140230739 @default.
- W2006416785 cites W1498924843 @default.
- W2006416785 cites W1561476021 @default.
- W2006416785 cites W1861165793 @default.
- W2006416785 cites W1969743795 @default.
- W2006416785 cites W1984882962 @default.
- W2006416785 cites W1987003587 @default.
- W2006416785 cites W1989571349 @default.
- W2006416785 cites W1991022711 @default.
- W2006416785 cites W1995444885 @default.
- W2006416785 cites W1998377076 @default.
- W2006416785 cites W2006062026 @default.
- W2006416785 cites W2009231148 @default.
- W2006416785 cites W2011338138 @default.
- W2006416785 cites W2016640431 @default.
- W2006416785 cites W2017784972 @default.
- W2006416785 cites W2024350731 @default.
- W2006416785 cites W2026238074 @default.
- W2006416785 cites W2026944113 @default.
- W2006416785 cites W2032659849 @default.
- W2006416785 cites W2035491291 @default.
- W2006416785 cites W2039268793 @default.
- W2006416785 cites W2041433712 @default.
- W2006416785 cites W2046198618 @default.
- W2006416785 cites W2050347351 @default.
- W2006416785 cites W2051148199 @default.
- W2006416785 cites W2052001330 @default.
- W2006416785 cites W2056438160 @default.
- W2006416785 cites W2065854375 @default.
- W2006416785 cites W2072040767 @default.
- W2006416785 cites W2073872036 @default.
- W2006416785 cites W2076595891 @default.
- W2006416785 cites W2077947904 @default.
- W2006416785 cites W2082719738 @default.
- W2006416785 cites W2082854271 @default.
- W2006416785 cites W2085126201 @default.
- W2006416785 cites W2090469736 @default.
- W2006416785 cites W2091888728 @default.
- W2006416785 cites W2096183596 @default.
- W2006416785 cites W2096451658 @default.
- W2006416785 cites W2098115340 @default.
- W2006416785 cites W2099105251 @default.
- W2006416785 cites W2105379349 @default.
- W2006416785 cites W2112318170 @default.
- W2006416785 cites W2116931343 @default.
- W2006416785 cites W2123502134 @default.
- W2006416785 cites W2124005596 @default.
- W2006416785 cites W2129701204 @default.
- W2006416785 cites W2130454895 @default.
- W2006416785 cites W2130531595 @default.
- W2006416785 cites W2133414972 @default.
- W2006416785 cites W2137093536 @default.
- W2006416785 cites W2142414495 @default.
- W2006416785 cites W2143057647 @default.
- W2006416785 cites W2145869960 @default.
- W2006416785 cites W2146543824 @default.
- W2006416785 cites W2153841727 @default.
- W2006416785 cites W2155208885 @default.
- W2006416785 cites W2157704325 @default.
- W2006416785 cites W2159068519 @default.
- W2006416785 cites W2160175617 @default.
- W2006416785 cites W2163986764 @default.
- W2006416785 cites W2165462764 @default.
- W2006416785 cites W2166639411 @default.
- W2006416785 cites W2178538035 @default.
- W2006416785 cites W2184621706 @default.
- W2006416785 doi "https://doi.org/10.1371/journal.pone.0007364" @default.
- W2006416785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754662" @default.
- W2006416785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19812700" @default.
- W2006416785 hasPublicationYear "2009" @default.
- W2006416785 type Work @default.
- W2006416785 sameAs 2006416785 @default.
- W2006416785 citedByCount "103" @default.
- W2006416785 countsByYear W20064167852012 @default.
- W2006416785 countsByYear W20064167852013 @default.
- W2006416785 countsByYear W20064167852014 @default.
- W2006416785 countsByYear W20064167852015 @default.
- W2006416785 countsByYear W20064167852016 @default.
- W2006416785 countsByYear W20064167852017 @default.
- W2006416785 countsByYear W20064167852018 @default.
- W2006416785 countsByYear W20064167852019 @default.