Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006418491> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2006418491 endingPage "S174" @default.
- W2006418491 startingPage "S174" @default.
- W2006418491 abstract "Chronic alcohol intake is known to induce permanent cognitive deficits along with enhanced oxidative–nitrosative stress and activation of neuroinflammatory cascade. In the present study, we investigated the protective effect of resveratrol, a natural polyphenolic phytoalexin against chronic alcohol-induced cognitive dysfunction and neuroiflammatory cascade in the brain of adult rats chronically administered ethanol. Male Wistar rats were adminstered ethanol (10 g/kg; oral gavage) for ten weeks and treated with resveratrol (5, 10 and 20 mg/kg) for the same duration. Ethanol-exposed rats showed impaired spatial navigation in the Morris water maze test and poor retention in the elevated plus maze task which was coupled with enhanced acetylcholinesterase activity, increased oxidative–nitrosative stress, cytokines (TNF-alpha and IL-1beta), NF-kappa β and caspase-3 levels in different brain regions (cerebral cortex and hippocampus) of ethanol-treated rats. Co-administration with resveratrol significantly and dose-dependently prevented all the behavioral, biochemical and molecular deficits. Correlatively, the results of the present study revealed that treatment with resveratrol significantly prevented cognitive deficits induced by chronic ethanol exposure not only by modulating oxido–nitrosative stress but also by attenuating the enhanced levels of pro-inflammatory cytokines (TNF-α and IL-1β), NF-kβ and caspase-3 in different brain regions of ethanol treated rats. Therefore, mechanism underlying the neuroprotective effects of resveratrol observed in our study may be due to its antioxidant, anti-inflammatory and neuromodulating activities." @default.
- W2006418491 created "2016-06-24" @default.
- W2006418491 creator A5003704331 @default.
- W2006418491 creator A5043446294 @default.
- W2006418491 creator A5046314894 @default.
- W2006418491 creator A5079918055 @default.
- W2006418491 creator A5081296113 @default.
- W2006418491 date "2007-03-01" @default.
- W2006418491 modified "2023-10-18" @default.
- W2006418491 title "Treatment with ect is associated with an increase of nitric oxide" @default.
- W2006418491 doi "https://doi.org/10.1016/j.eurpsy.2007.01.571" @default.
- W2006418491 hasPublicationYear "2007" @default.
- W2006418491 type Work @default.
- W2006418491 sameAs 2006418491 @default.
- W2006418491 citedByCount "0" @default.
- W2006418491 crossrefType "journal-article" @default.
- W2006418491 hasAuthorship W2006418491A5003704331 @default.
- W2006418491 hasAuthorship W2006418491A5043446294 @default.
- W2006418491 hasAuthorship W2006418491A5046314894 @default.
- W2006418491 hasAuthorship W2006418491A5079918055 @default.
- W2006418491 hasAuthorship W2006418491A5081296113 @default.
- W2006418491 hasConcept C126322002 @default.
- W2006418491 hasConcept C134018914 @default.
- W2006418491 hasConcept C185592680 @default.
- W2006418491 hasConcept C25498285 @default.
- W2006418491 hasConcept C2776151105 @default.
- W2006418491 hasConcept C2776816829 @default.
- W2006418491 hasConcept C2780161600 @default.
- W2006418491 hasConcept C2781161787 @default.
- W2006418491 hasConcept C44752575 @default.
- W2006418491 hasConcept C519581460 @default.
- W2006418491 hasConcept C55493867 @default.
- W2006418491 hasConcept C71924100 @default.
- W2006418491 hasConcept C98274493 @default.
- W2006418491 hasConceptScore W2006418491C126322002 @default.
- W2006418491 hasConceptScore W2006418491C134018914 @default.
- W2006418491 hasConceptScore W2006418491C185592680 @default.
- W2006418491 hasConceptScore W2006418491C25498285 @default.
- W2006418491 hasConceptScore W2006418491C2776151105 @default.
- W2006418491 hasConceptScore W2006418491C2776816829 @default.
- W2006418491 hasConceptScore W2006418491C2780161600 @default.
- W2006418491 hasConceptScore W2006418491C2781161787 @default.
- W2006418491 hasConceptScore W2006418491C44752575 @default.
- W2006418491 hasConceptScore W2006418491C519581460 @default.
- W2006418491 hasConceptScore W2006418491C55493867 @default.
- W2006418491 hasConceptScore W2006418491C71924100 @default.
- W2006418491 hasConceptScore W2006418491C98274493 @default.
- W2006418491 hasLocation W20064184911 @default.
- W2006418491 hasOpenAccess W2006418491 @default.
- W2006418491 hasPrimaryLocation W20064184911 @default.
- W2006418491 hasRelatedWork W170415342 @default.
- W2006418491 hasRelatedWork W1978555483 @default.
- W2006418491 hasRelatedWork W1986000820 @default.
- W2006418491 hasRelatedWork W2051942816 @default.
- W2006418491 hasRelatedWork W2167226448 @default.
- W2006418491 hasRelatedWork W2167950893 @default.
- W2006418491 hasRelatedWork W2375813713 @default.
- W2006418491 hasRelatedWork W3165067801 @default.
- W2006418491 hasRelatedWork W4303699395 @default.
- W2006418491 hasRelatedWork W4375864803 @default.
- W2006418491 hasVolume "22" @default.
- W2006418491 isParatext "false" @default.
- W2006418491 isRetracted "false" @default.
- W2006418491 magId "2006418491" @default.
- W2006418491 workType "article" @default.