Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006430022> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2006430022 endingPage "733" @default.
- W2006430022 startingPage "728" @default.
- W2006430022 abstract "We investigated the protective effects of an adenosine triphosphate-sensitive potassium channel opener nicorandil in the rabbit model of spinal cord ischemia.Rabbits were randomized into 4 groups (each n = 6): the nicorandil group (100 microg/kg intravenous nicorandil 10 minutes before ischemia); the glibenclamide plus nicorandil group (3 mg/kg intravenous glibenclamide, an antagonist of adenosine triphosphate-sensitive potassium channels, 10 minutes before nicorandil administration); the vehicle group (vehicle alone); and the sham operation group (without spinal cord ischemia). Spinal cord ischemia was induced by balloon occlusion of the infrarenal abdominal aorta for 15 minutes at 39 degrees C. Neurologic function was graded into Johnson's score at 8 hours, 1 day, and 2 days. Histopathologic examination was performed at 2 days, and the number of intact motor neuron cells was compared.Johnson scores of the glibenclamide plus nicorandil and vehicle groups were significantly lower than those of the sham operation and nicorandil groups at each time point, and no statistically significant difference was observed between the glibenclamide plus nicorandil and vehicle groups. Histopathologic examination revealed that motor neurons were almost normal in the nicorandil group, whereas about 55% of motor neurons were lost in the vehicle and glibenclamide plus nicorandil groups.Nicorandil has a protective effect on the ischemic rabbit spinal cord, and the beneficial effect seems mediated through the activation of adenosine triphosphate-sensitive potassium channels." @default.
- W2006430022 created "2016-06-24" @default.
- W2006430022 creator A5023021091 @default.
- W2006430022 creator A5023225309 @default.
- W2006430022 creator A5048353164 @default.
- W2006430022 creator A5068806899 @default.
- W2006430022 creator A5080422342 @default.
- W2006430022 date "2001-10-01" @default.
- W2006430022 modified "2023-10-11" @default.
- W2006430022 title "The adenosine triphosphate–sensitive potassium channel opener nicorandil protects the ischemic rabbit spinal cord" @default.
- W2006430022 cites W1977291173 @default.
- W2006430022 cites W1981994273 @default.
- W2006430022 cites W1987792091 @default.
- W2006430022 cites W1988513665 @default.
- W2006430022 cites W2008309264 @default.
- W2006430022 cites W2018290421 @default.
- W2006430022 cites W2019479676 @default.
- W2006430022 cites W2026314659 @default.
- W2006430022 cites W2041671679 @default.
- W2006430022 cites W2044074327 @default.
- W2006430022 cites W2046949592 @default.
- W2006430022 cites W2047908358 @default.
- W2006430022 cites W2059640915 @default.
- W2006430022 cites W2068302673 @default.
- W2006430022 cites W2088595348 @default.
- W2006430022 cites W2096442918 @default.
- W2006430022 cites W2105812089 @default.
- W2006430022 cites W2133726443 @default.
- W2006430022 cites W2137083867 @default.
- W2006430022 doi "https://doi.org/10.1067/mtc.2001.115703" @default.
- W2006430022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11581605" @default.
- W2006430022 hasPublicationYear "2001" @default.
- W2006430022 type Work @default.
- W2006430022 sameAs 2006430022 @default.
- W2006430022 citedByCount "16" @default.
- W2006430022 countsByYear W20064300222013 @default.
- W2006430022 countsByYear W20064300222021 @default.
- W2006430022 countsByYear W20064300222022 @default.
- W2006430022 crossrefType "journal-article" @default.
- W2006430022 hasAuthorship W2006430022A5023021091 @default.
- W2006430022 hasAuthorship W2006430022A5023225309 @default.
- W2006430022 hasAuthorship W2006430022A5048353164 @default.
- W2006430022 hasAuthorship W2006430022A5068806899 @default.
- W2006430022 hasAuthorship W2006430022A5080422342 @default.
- W2006430022 hasBestOaLocation W20064300221 @default.
- W2006430022 hasConcept C118552586 @default.
- W2006430022 hasConcept C126322002 @default.
- W2006430022 hasConcept C134018914 @default.
- W2006430022 hasConcept C2776309818 @default.
- W2006430022 hasConcept C2777194220 @default.
- W2006430022 hasConcept C2778902376 @default.
- W2006430022 hasConcept C2779768347 @default.
- W2006430022 hasConcept C2780775167 @default.
- W2006430022 hasConcept C42219234 @default.
- W2006430022 hasConcept C541997718 @default.
- W2006430022 hasConcept C555293320 @default.
- W2006430022 hasConcept C71924100 @default.
- W2006430022 hasConcept C83743174 @default.
- W2006430022 hasConcept C98274493 @default.
- W2006430022 hasConceptScore W2006430022C118552586 @default.
- W2006430022 hasConceptScore W2006430022C126322002 @default.
- W2006430022 hasConceptScore W2006430022C134018914 @default.
- W2006430022 hasConceptScore W2006430022C2776309818 @default.
- W2006430022 hasConceptScore W2006430022C2777194220 @default.
- W2006430022 hasConceptScore W2006430022C2778902376 @default.
- W2006430022 hasConceptScore W2006430022C2779768347 @default.
- W2006430022 hasConceptScore W2006430022C2780775167 @default.
- W2006430022 hasConceptScore W2006430022C42219234 @default.
- W2006430022 hasConceptScore W2006430022C541997718 @default.
- W2006430022 hasConceptScore W2006430022C555293320 @default.
- W2006430022 hasConceptScore W2006430022C71924100 @default.
- W2006430022 hasConceptScore W2006430022C83743174 @default.
- W2006430022 hasConceptScore W2006430022C98274493 @default.
- W2006430022 hasIssue "4" @default.
- W2006430022 hasLocation W20064300221 @default.
- W2006430022 hasLocation W20064300222 @default.
- W2006430022 hasOpenAccess W2006430022 @default.
- W2006430022 hasPrimaryLocation W20064300221 @default.
- W2006430022 hasRelatedWork W1560414868 @default.
- W2006430022 hasRelatedWork W2006430022 @default.
- W2006430022 hasRelatedWork W2035241463 @default.
- W2006430022 hasRelatedWork W2061802839 @default.
- W2006430022 hasRelatedWork W21463425 @default.
- W2006430022 hasRelatedWork W2290153811 @default.
- W2006430022 hasRelatedWork W2417443126 @default.
- W2006430022 hasRelatedWork W2430991331 @default.
- W2006430022 hasRelatedWork W2792581798 @default.
- W2006430022 hasRelatedWork W59281060 @default.
- W2006430022 hasVolume "122" @default.
- W2006430022 isParatext "false" @default.
- W2006430022 isRetracted "false" @default.
- W2006430022 magId "2006430022" @default.
- W2006430022 workType "article" @default.