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• W2006452078 abstract "[6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale Roscoe, Zingiberaceae) and has diverse pharmacologic effects. Here, we describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo. In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase-3, -8, -9, and Fas expression. It also reduced UVB-induced expression and transactivation of COX-2. Translocation of NF-κB from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of IκBα phosphorylation (ser-32). Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 μM) prior to UVB irradiation (5 kJ/m2) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-κB translocation. These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders." @default.
• W2006452078 created "2016-06-24" @default.
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• W2006452078 date "2007-01-01" @default.
• W2006452078 modified "2023-10-17" @default.
• W2006452078 title "[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression<i>in vitro</i>and<i>in vivo</i>" @default.
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• W2006452078 doi "https://doi.org/10.1080/10715760701209896" @default.
• W2006452078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17454143" @default.
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