FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006454502> ?p ?o ?g. }

• W2006454502 endingPage "595" @default.
• W2006454502 startingPage "595" @default.
• W2006454502 abstract "The significant antiacanthamoebal effect of benzalkonium chloride, at or below concentrations used for preservation of common ophthalmic preparations, should be understood both when choosing empiric antibiotic therapy for infectious keratitis and when assessing the persistent rise in Acanthamoeba cases in the United States since 2003.To characterize the antiacanthamoebal efficacy of low concentrations of benzalkonium chloride (BAK) for drug preservation and therapeutic effect against Acanthamoeba.Experimental study with a review of the literature.Laboratory.A concentration of 10(4) trophozoites of 3 well-characterized clinical strains of Acanthamoeba were exposed at 0.5, 2.0, 3.5, 5.0, and 6.5 hours to BAK (0.001%, 0.002%, and 0.003%), moxifloxacin hydrochloride (0.5%), and moxifloxacin (0.5%) + BAK (0.001% and 0.003%) with hydrogen peroxide (3%) and amoeba saline controls.Amoeba survival was calculated using the most probable number method recorded as log kill values. The relationship of BAK concentration and exposure time as well as the relative effect of BAK and moxifloxacin on acanthamoebal survival were analyzed.Amoebicidal activity of BAK is both time dependent and concentration dependent in pooled and strain-stratified analyses (P < .001). Moxifloxacin demonstrated no significant independent inhibitory effect or additive effect to BAK efficacy on acanthamoebal survival. The profound antiacanthamoebal effect of BAK, 0.003%, was similar to that of hydrogen peroxide for certain strains.Low concentrations of BAK, previously demonstrated to concentrate and persist in ocular surface epithelium, exhibit significant antiacanthamoebal activity in vitro at or below concentrations found in commercially available ophthalmic anti-infectives. The unexplained persistence of the Acanthamoeba keratitis outbreak in the United States, clusters abroad, and clinical studies reporting resolution or modification of Acanthamoeba keratitis without specific antiacanthamoebal therapy suggests that other contributing factors should be considered, including changes in the formulations used for empirical therapy of presumed infectious keratitis occurring in the same period." @default.
• W2006454502 created "2016-06-24" @default.
• W2006454502 creator A5029159944 @default.
• W2006454502 creator A5034648190 @default.
• W2006454502 creator A5044457669 @default.
• W2006454502 creator A5063712566 @default.
• W2006454502 date "2013-05-01" @default.
• W2006454502 modified "2023-09-23" @default.
• W2006454502 title "Effect of Low Concentrations of Benzalkonium Chloride on Acanthamoebal Survival and Its Potential Impact on Empirical Therapy of Infectious Keratitis" @default.
• W2006454502 cites W1780069944 @default.
• W2006454502 cites W1965392945 @default.
• W2006454502 cites W1969832384 @default.
• W2006454502 cites W1970222045 @default.
• W2006454502 cites W1970541239 @default.
• W2006454502 cites W1973742373 @default.
• W2006454502 cites W1976635568 @default.
• W2006454502 cites W1984563949 @default.
• W2006454502 cites W1995838178 @default.
• W2006454502 cites W2007331787 @default.
• W2006454502 cites W2015769584 @default.
• W2006454502 cites W2043098528 @default.
• W2006454502 cites W2057145634 @default.
• W2006454502 cites W2060431677 @default.
• W2006454502 cites W2061465974 @default.
• W2006454502 cites W2068610969 @default.
• W2006454502 cites W2071416432 @default.
• W2006454502 cites W2071954849 @default.
• W2006454502 cites W2077594497 @default.
• W2006454502 cites W2078063864 @default.
• W2006454502 cites W2078429928 @default.
• W2006454502 cites W2078899749 @default.
• W2006454502 cites W2091866314 @default.
• W2006454502 cites W2092698254 @default.
• W2006454502 cites W2092942446 @default.
• W2006454502 cites W2107265364 @default.
• W2006454502 cites W2108983451 @default.
• W2006454502 cites W2116582646 @default.
• W2006454502 cites W2120118081 @default.
• W2006454502 cites W2121379707 @default.
• W2006454502 cites W2130938401 @default.
• W2006454502 cites W2133589872 @default.
• W2006454502 cites W2153077021 @default.
• W2006454502 cites W2157475963 @default.
• W2006454502 cites W2399608055 @default.
• W2006454502 doi "https://doi.org/10.1001/jamaophthalmol.2013.1644" @default.
• W2006454502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7430836" @default.
• W2006454502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23519403" @default.
• W2006454502 hasPublicationYear "2013" @default.
• W2006454502 type Work @default.
• W2006454502 sameAs 2006454502 @default.
• W2006454502 citedByCount "11" @default.
• W2006454502 countsByYear W20064545022014 @default.
• W2006454502 countsByYear W20064545022017 @default.
• W2006454502 countsByYear W20064545022018 @default.
• W2006454502 countsByYear W20064545022019 @default.
• W2006454502 countsByYear W20064545022021 @default.
• W2006454502 countsByYear W20064545022022 @default.
• W2006454502 countsByYear W20064545022023 @default.
• W2006454502 crossrefType "journal-article" @default.
• W2006454502 hasAuthorship W2006454502A5029159944 @default.
• W2006454502 hasAuthorship W2006454502A5034648190 @default.
• W2006454502 hasAuthorship W2006454502A5044457669 @default.
• W2006454502 hasAuthorship W2006454502A5063712566 @default.
• W2006454502 hasBestOaLocation W20064545021 @default.
• W2006454502 hasConcept C142724271 @default.
• W2006454502 hasConcept C16005928 @default.
• W2006454502 hasConcept C176947019 @default.
• W2006454502 hasConcept C2775919038 @default.
• W2006454502 hasConcept C2778560704 @default.
• W2006454502 hasConcept C2778836808 @default.
• W2006454502 hasConcept C2778868110 @default.
• W2006454502 hasConcept C2780576314 @default.
• W2006454502 hasConcept C501593827 @default.
• W2006454502 hasConcept C71924100 @default.
• W2006454502 hasConcept C86803240 @default.
• W2006454502 hasConcept C89423630 @default.
• W2006454502 hasConcept C98274493 @default.
• W2006454502 hasConceptScore W2006454502C142724271 @default.
• W2006454502 hasConceptScore W2006454502C16005928 @default.
• W2006454502 hasConceptScore W2006454502C176947019 @default.
• W2006454502 hasConceptScore W2006454502C2775919038 @default.
• W2006454502 hasConceptScore W2006454502C2778560704 @default.
• W2006454502 hasConceptScore W2006454502C2778836808 @default.
• W2006454502 hasConceptScore W2006454502C2778868110 @default.
• W2006454502 hasConceptScore W2006454502C2780576314 @default.
• W2006454502 hasConceptScore W2006454502C501593827 @default.
• W2006454502 hasConceptScore W2006454502C71924100 @default.
• W2006454502 hasConceptScore W2006454502C86803240 @default.
• W2006454502 hasConceptScore W2006454502C89423630 @default.
• W2006454502 hasConceptScore W2006454502C98274493 @default.
• W2006454502 hasIssue "5" @default.
• W2006454502 hasLocation W20064545021 @default.
• W2006454502 hasLocation W20064545022 @default.
• W2006454502 hasLocation W20064545023 @default.
• W2006454502 hasOpenAccess W2006454502 @default.
• W2006454502 hasPrimaryLocation W20064545021 @default.
• W2006454502 hasRelatedWork W1505315422 @default.
• W2006454502 hasRelatedWork W1966159217 @default.

• next