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- W2006454600 abstract "The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 15 analogs of 2-methoxyestradiol (1) are reported. The biological studies revealed that the position of nitrogen atom in the heterocyclic ring is important for inhibition of both tubulin polymerization and angiogenesis. The most potent inhibitors were compounds 11f and 13e, with a 6-substituted isoquinoline ring in the 17-position of the steroid skeleton. Moreover, low estrogen activity was observed for the analogs tested at 10 μM concentrations." @default.
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- W2006454600 date "2014-10-01" @default.
- W2006454600 modified "2023-09-30" @default.
- W2006454600 title "Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis" @default.
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- W2006454600 doi "https://doi.org/10.1016/j.ejmech.2014.08.002" @default.
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