Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006472037> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2006472037 endingPage "657" @default.
- W2006472037 startingPage "650" @default.
- W2006472037 abstract "Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein synthesis and maturation and is essential for bacterial survival. Its apparent absence from mammalian organisms makes it an attractive target for designing novel antibacterial agents. Based on the substrate specificity of peptide deformylase from Escherichia coli, a focused library of peptide thiols was synthesized on TentaGel resin using a disulfide linkage. Screening of the library against the purified deformylase was carried out in solution phase after the inhibitors were released from the resin with a reducing agent. A potent deformylase inhibitor was obtained from a 750-member library and was further optimized through rational modification into a low nanomolar inhibitor (KI = 15 nM against E. coli deformylase)." @default.
- W2006472037 created "2016-06-24" @default.
- W2006472037 creator A5027490120 @default.
- W2006472037 creator A5027822147 @default.
- W2006472037 creator A5051990628 @default.
- W2006472037 creator A5063942589 @default.
- W2006472037 creator A5090864700 @default.
- W2006472037 date "2000-09-16" @default.
- W2006472037 modified "2023-10-16" @default.
- W2006472037 title "Identification of a Potent Peptide Deformylase Inhibitor from a Rationally Designed Combinatorial Library" @default.
- W2006472037 cites W1509733399 @default.
- W2006472037 cites W1773975057 @default.
- W2006472037 cites W1932542519 @default.
- W2006472037 cites W1969468293 @default.
- W2006472037 cites W1969594643 @default.
- W2006472037 cites W1975144490 @default.
- W2006472037 cites W1987166705 @default.
- W2006472037 cites W2007301486 @default.
- W2006472037 cites W2011271534 @default.
- W2006472037 cites W2031415145 @default.
- W2006472037 cites W2040564101 @default.
- W2006472037 cites W2041719513 @default.
- W2006472037 cites W2043876163 @default.
- W2006472037 cites W2045741530 @default.
- W2006472037 cites W2046715095 @default.
- W2006472037 cites W2050320436 @default.
- W2006472037 cites W2055608110 @default.
- W2006472037 cites W2055648941 @default.
- W2006472037 cites W2055749408 @default.
- W2006472037 cites W2089571021 @default.
- W2006472037 cites W2132897827 @default.
- W2006472037 cites W2134672977 @default.
- W2006472037 doi "https://doi.org/10.1021/cc000036n" @default.
- W2006472037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11126293" @default.
- W2006472037 hasPublicationYear "2000" @default.
- W2006472037 type Work @default.
- W2006472037 sameAs 2006472037 @default.
- W2006472037 citedByCount "27" @default.
- W2006472037 countsByYear W20064720372014 @default.
- W2006472037 countsByYear W20064720372017 @default.
- W2006472037 countsByYear W20064720372019 @default.
- W2006472037 countsByYear W20064720372021 @default.
- W2006472037 crossrefType "journal-article" @default.
- W2006472037 hasAuthorship W2006472037A5027490120 @default.
- W2006472037 hasAuthorship W2006472037A5027822147 @default.
- W2006472037 hasAuthorship W2006472037A5051990628 @default.
- W2006472037 hasAuthorship W2006472037A5063942589 @default.
- W2006472037 hasAuthorship W2006472037A5090864700 @default.
- W2006472037 hasConcept C104317684 @default.
- W2006472037 hasConcept C167625842 @default.
- W2006472037 hasConcept C185592680 @default.
- W2006472037 hasConcept C18903297 @default.
- W2006472037 hasConcept C21951064 @default.
- W2006472037 hasConcept C2776471321 @default.
- W2006472037 hasConcept C2777289219 @default.
- W2006472037 hasConcept C2779281246 @default.
- W2006472037 hasConcept C2780104969 @default.
- W2006472037 hasConcept C2993778972 @default.
- W2006472037 hasConcept C523546767 @default.
- W2006472037 hasConcept C54355233 @default.
- W2006472037 hasConcept C547475151 @default.
- W2006472037 hasConcept C55493867 @default.
- W2006472037 hasConcept C86803240 @default.
- W2006472037 hasConceptScore W2006472037C104317684 @default.
- W2006472037 hasConceptScore W2006472037C167625842 @default.
- W2006472037 hasConceptScore W2006472037C185592680 @default.
- W2006472037 hasConceptScore W2006472037C18903297 @default.
- W2006472037 hasConceptScore W2006472037C21951064 @default.
- W2006472037 hasConceptScore W2006472037C2776471321 @default.
- W2006472037 hasConceptScore W2006472037C2777289219 @default.
- W2006472037 hasConceptScore W2006472037C2779281246 @default.
- W2006472037 hasConceptScore W2006472037C2780104969 @default.
- W2006472037 hasConceptScore W2006472037C2993778972 @default.
- W2006472037 hasConceptScore W2006472037C523546767 @default.
- W2006472037 hasConceptScore W2006472037C54355233 @default.
- W2006472037 hasConceptScore W2006472037C547475151 @default.
- W2006472037 hasConceptScore W2006472037C55493867 @default.
- W2006472037 hasConceptScore W2006472037C86803240 @default.
- W2006472037 hasIssue "6" @default.
- W2006472037 hasLocation W20064720371 @default.
- W2006472037 hasLocation W20064720372 @default.
- W2006472037 hasOpenAccess W2006472037 @default.
- W2006472037 hasPrimaryLocation W20064720371 @default.
- W2006472037 hasRelatedWork W1909802592 @default.
- W2006472037 hasRelatedWork W2078683866 @default.
- W2006472037 hasRelatedWork W2098498035 @default.
- W2006472037 hasRelatedWork W2150087752 @default.
- W2006472037 hasRelatedWork W2354214183 @default.
- W2006472037 hasRelatedWork W2364756590 @default.
- W2006472037 hasRelatedWork W2376972434 @default.
- W2006472037 hasRelatedWork W2385803481 @default.
- W2006472037 hasRelatedWork W2387731647 @default.
- W2006472037 hasRelatedWork W2390509371 @default.
- W2006472037 hasVolume "2" @default.
- W2006472037 isParatext "false" @default.
- W2006472037 isRetracted "false" @default.
- W2006472037 magId "2006472037" @default.
- W2006472037 workType "article" @default.