FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006501913> ?p ?o ?g. }

• W2006501913 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCThe incidence of hepatocellular carcinoma (HCC) has doubled over the past 20 years in the United States (US). HCC prognosis is poor if not diagnosed and treated at an early stage. MicroRNAs (miRNAs) are a class of small non-coding RNAs that control gene expression by inhibiting translation or inducing cleavage of target messenger RNAs (mRNAs). miRNAs can regulate diverse biological processes including DNA repair, apoptosis, cell proliferation, differentiation and immune function. Circulating miRNAs in cell-free plasma/serum samples have been consistently observed to have high stability and resistance to storage/handling, suggesting their potential use as diagnostic biomarkers. We conducted a two-phase epidemiological case-control study to test the hypothesis that genome-wide dysregulation of circulating miRNAs differentiate HCC cases from controls. A total of 69 HCC patients and 69 controls were recruited and matched on age, gender and ethnicity. Taqman low density arrays were used to examine genome-wide miRNA expression, and quantitative RT-PCR was used to validate promising candidates. Sixty-six miRNAs were found to be significantly over-expressed in plasma of HCC cases compared to controls after adjusting for false discovery rate (p<0.05). A volcano plot indicated that 7 miRNAs had over 2-fold case-control differences with p<0.01. Four significant miRNAs (miR-150, miR-30c, miR-483-5p and miR-520b) detectable in all samples with varied expression levels were further validated in an expanded case-control study. MiR-483-5p was statistically significantly over-expressed in HCC cases compared with controls (3.25 vs. 0.54, p<0.0001). MiR-150 was up-regulated in HCC, but the difference was not significant (5.66 vs. 5.29). The combination of plasma levels of miR-483-5p and miR-150 can significantly differentiate HCC cases from controls with an AUC of 0.850 (p<0.0001). The sensitivity and specificity were, respectively, 63.8% and 85.5%. These preliminary data indicated the importance of dysregulated circulating miRNAs in hepatocarcinogenesis, and suggesting the possibility of using miR-483-5p and miR-150 as diagnostic biomarkers. Large prospective studies are necessary to replicate the current findings, and evaluate the panel of circulating miRNAs in improving early diagnosis of HCC.Citation Format: Jing Shen, Antai Wang, Qiao Wang, Irina Gurvich, Abby B. Siegel, Helen Remotti, Regina M. Santella. Exploration of genome-wide circulating microRNA in hepatocellular carcinoma (HCC) - dysregulation of miR-483-5p and miR-150 as diagnostic marker. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-25. doi:10.1158/1538-7445.AM2013-LB-25" @default.
• W2006501913 created "2016-06-24" @default.
• W2006501913 creator A5001563233 @default.
• W2006501913 creator A5037348006 @default.
• W2006501913 creator A5047736184 @default.
• W2006501913 creator A5063128545 @default.
• W2006501913 creator A5076983797 @default.
• W2006501913 creator A5084377118 @default.
• W2006501913 creator A5087378677 @default.
• W2006501913 date "2013-04-15" @default.
• W2006501913 modified "2023-09-30" @default.
• W2006501913 title "Abstract LB-25: Exploration of genome-wide circulating microRNA in hepatocellular carcinoma (HCC) - dysregulation of miR-483-5p and miR-150 as diagnostic marker." @default.
• W2006501913 doi "https://doi.org/10.1158/1538-7445.am2013-lb-25" @default.
• W2006501913 hasPublicationYear "2013" @default.
• W2006501913 type Work @default.
• W2006501913 sameAs 2006501913 @default.
• W2006501913 citedByCount "0" @default.
• W2006501913 crossrefType "proceedings-article" @default.
• W2006501913 hasAuthorship W2006501913A5001563233 @default.
• W2006501913 hasAuthorship W2006501913A5037348006 @default.
• W2006501913 hasAuthorship W2006501913A5047736184 @default.
• W2006501913 hasAuthorship W2006501913A5063128545 @default.
• W2006501913 hasAuthorship W2006501913A5076983797 @default.
• W2006501913 hasAuthorship W2006501913A5084377118 @default.
• W2006501913 hasAuthorship W2006501913A5087378677 @default.
• W2006501913 hasConcept C104317684 @default.
• W2006501913 hasConcept C121608353 @default.
• W2006501913 hasConcept C143660080 @default.
• W2006501913 hasConcept C143998085 @default.
• W2006501913 hasConcept C145059251 @default.
• W2006501913 hasConcept C203014093 @default.
• W2006501913 hasConcept C2778019345 @default.
• W2006501913 hasConcept C48023723 @default.
• W2006501913 hasConcept C502942594 @default.
• W2006501913 hasConcept C54355233 @default.
• W2006501913 hasConcept C71924100 @default.
• W2006501913 hasConcept C86803240 @default.
• W2006501913 hasConceptScore W2006501913C104317684 @default.
• W2006501913 hasConceptScore W2006501913C121608353 @default.
• W2006501913 hasConceptScore W2006501913C143660080 @default.
• W2006501913 hasConceptScore W2006501913C143998085 @default.
• W2006501913 hasConceptScore W2006501913C145059251 @default.
• W2006501913 hasConceptScore W2006501913C203014093 @default.
• W2006501913 hasConceptScore W2006501913C2778019345 @default.
• W2006501913 hasConceptScore W2006501913C48023723 @default.
• W2006501913 hasConceptScore W2006501913C502942594 @default.
• W2006501913 hasConceptScore W2006501913C54355233 @default.
• W2006501913 hasConceptScore W2006501913C71924100 @default.
• W2006501913 hasConceptScore W2006501913C86803240 @default.
• W2006501913 hasLocation W20065019131 @default.
• W2006501913 hasOpenAccess W2006501913 @default.
• W2006501913 hasPrimaryLocation W20065019131 @default.
• W2006501913 hasRelatedWork W1141573380 @default.
• W2006501913 hasRelatedWork W1154407209 @default.
• W2006501913 hasRelatedWork W2015188461 @default.
• W2006501913 hasRelatedWork W2052800146 @default.
• W2006501913 hasRelatedWork W2073423022 @default.
• W2006501913 hasRelatedWork W2131081587 @default.
• W2006501913 hasRelatedWork W2261737322 @default.
• W2006501913 hasRelatedWork W2319152248 @default.
• W2006501913 hasRelatedWork W2339383276 @default.
• W2006501913 hasRelatedWork W2553891194 @default.
• W2006501913 hasRelatedWork W2890777887 @default.
• W2006501913 hasRelatedWork W3003686046 @default.
• W2006501913 hasRelatedWork W3012156078 @default.
• W2006501913 hasRelatedWork W3049241683 @default.
• W2006501913 hasRelatedWork W3111836495 @default.
• W2006501913 hasRelatedWork W3147130575 @default.
• W2006501913 hasRelatedWork W3159653393 @default.
• W2006501913 hasRelatedWork W3165010514 @default.
• W2006501913 hasRelatedWork W3203440645 @default.
• W2006501913 hasRelatedWork W3023592636 @default.
• W2006501913 isParatext "false" @default.
• W2006501913 isRetracted "false" @default.
• W2006501913 magId "2006501913" @default.
• W2006501913 workType "article" @default.