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- W2006502865 abstract "<h2>Abstract</h2> The influence of tumor size on radiation response was studied in the Lewis lung carcinoma as a model to evaluate the radiosensitivity of microscopic or subclinical metastatic tumor deposits. Tumor cell survival analysis following <i>in situ</i><sup>60</sup>Co γ-irradiation showed that cells in 1 mm diameter (0·5 mm<sup>3</sup>) pulmonary metastases were markedly more radiosensitive (<i>D</i><sub>0</sub> = 106 rad, hypoxic fraction < 0·005) than those in 500 mm<sup>3</sup> subcutaneous tumors (final <i>D</i><sub>0</sub> = 309 rad, hypoxic fraction=0·36). Thus, unlike the large subcutaneous tumors, the 1 mm diameter metastases were nearly fully perfused with oxygen by an <i>in situ</i> tumor microvasculature. In addition the oxygenated cells from the small tumors were more radiosensitive (<i>D</i><sub>0</sub> = 89 rad) than those from the large subcutaneous tumors (<i>D</i><sub>0</sub> = 111 rad). These results may in part help explain and predict the success of regional radiotherapy in controlling subclinical regional deposits of metastatic carcinoma." @default.
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- W2006502865 title "Enhanced tumor cell radiosensitivity in artificial pulmonary metastases of the lewis lung carcinoma" @default.
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- W2006502865 doi "https://doi.org/10.1016/0360-3016(76)90048-1" @default.
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