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• W2006506516 abstract "As an attempt to search for bioactive natural constituents exerting antinociceptive and antiinflammatory activities, we examined the potency of the extract of Rubus coreanus fruits by the activity-guided fractionation. The EtOAc- and BuOH fraction and those alkaline hydrolysates showed significant antinociceptive effects as assessed by writhing-, hot plate- and tail flicks tests in mice and rats as well as antiinflammatory effect in rats with carrageenan-induced edema. BuOH extract was subjected to column chromatography to obtain a large amount of niga-ichigoside F1 (1,23-hydroxytormentic acid 28-O-glc), which was again hydrolyzed in NaOH solution to yield an aglycone 23-hydroxytormentic acid (1a). The aglycone, 23-hydroxytormentic acid, was much more potent in both antinociceptive and antiinflammatory tests than the glycoside, niga-ichigoside F1. The antiinflammatory effects of these compounds were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxyl radical in serum. These results suggested that 23-hydroxytormentic acid might be an active moiety of niga-ichigoside F1 present in R. coreanus." @default.
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• W2006506516 date "2003-01-01" @default.
• W2006506516 modified "2023-09-26" @default.
• W2006506516 title "Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus" @default.
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• W2006506516 doi "https://doi.org/10.1248/bpb.26.1436" @default.
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