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- W2006509079 abstract "Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4(+) FOXP3(+) CD127(-/low); Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP3(-), CD45RO(+) CD4(+) T cells which coproduce IL-10 and IFN-gamma. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation." @default.
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- W2006509079 date "2009-04-03" @default.
- W2006509079 modified "2023-10-05" @default.
- W2006509079 title "Distinct Roles for FOXP3+ and FOXP3− CD4+ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria" @default.
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- W2006509079 cites W1973007471 @default.
- W2006509079 cites W1973200069 @default.
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- W2006509079 cites W1974781378 @default.
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- W2006509079 cites W1984909066 @default.
- W2006509079 cites W1985544838 @default.
- W2006509079 cites W1985970889 @default.
- W2006509079 cites W1992496526 @default.
- W2006509079 cites W1994382879 @default.
- W2006509079 cites W1996058351 @default.
- W2006509079 cites W1998858806 @default.
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- W2006509079 cites W2018308106 @default.
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- W2006509079 cites W2022636507 @default.
- W2006509079 cites W2039113023 @default.
- W2006509079 cites W2039227742 @default.
- W2006509079 cites W2039683692 @default.
- W2006509079 cites W2039976430 @default.
- W2006509079 cites W2046226287 @default.
- W2006509079 cites W2049946738 @default.
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- W2006509079 cites W2066403587 @default.
- W2006509079 cites W2066499419 @default.
- W2006509079 cites W2072697409 @default.
- W2006509079 cites W2083508061 @default.
- W2006509079 cites W2085077927 @default.
- W2006509079 cites W2092855664 @default.
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- W2006509079 cites W2123249923 @default.
- W2006509079 cites W2124232678 @default.
- W2006509079 cites W2130351191 @default.
- W2006509079 cites W2133642262 @default.
- W2006509079 cites W2135490630 @default.
- W2006509079 cites W2136097155 @default.
- W2006509079 cites W2140559651 @default.
- W2006509079 cites W2141609293 @default.
- W2006509079 cites W2142734924 @default.
- W2006509079 cites W2143514176 @default.
- W2006509079 cites W2157498422 @default.
- W2006509079 cites W2158092720 @default.
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- W2006509079 cites W2162558450 @default.
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- W2006509079 cites W2168707849 @default.
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- W2006509079 doi "https://doi.org/10.1371/journal.ppat.1000364" @default.
- W2006509079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2658808" @default.
- W2006509079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19343213" @default.
- W2006509079 hasPublicationYear "2009" @default.
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