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- W2006516954 abstract "Preeclampsia (PE) is characterized by hypertension and proteinuria. A predisposition to endothelial dysfunction, which may trigger abnormal activation of the hemostatic and/or inflammatory systems, is thought to play a crucial part in pathogenesis of PE. We investigated the relationship between hemostatic and inflammatory parameters in women with severe PE.D-Dimer, PAI-1, IL-8, IL-6, TNF-α, and IFN-γ concentrations were measured in 59 pregnant women with severe PE (sPE), 49 normotensive pregnant and 48 non-pregnant women.D-Dimer and PAI-1 were higher in women with sPE compared to normotensive pregnant and non-pregnant women. IL-8, IL-6, and IFN-γ also were higher in women with sPE compared to normotensive pregnant women. However, only IL-6 and IFN-γ were higher in women with sPE compared to non-pregnant women. Moreover, D-Dimer and PAI-1 showed an elevated area under ROC curve proving to be excellent for discriminating sPE. Correlation analysis showed a weak correlation between D-Dimer and IL-8 and between PAI-1 and IFN-γ in sPE.D-Di and PAI-1 concentrations showed to be an important tool for monitoring sPE." @default.
- W2006516954 created "2016-06-24" @default.
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- W2006516954 date "2014-01-01" @default.
- W2006516954 modified "2023-10-10" @default.
- W2006516954 title "Severe preeclampsia: Are hemostatic and inflammatory parameters associated?" @default.
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- W2006516954 doi "https://doi.org/10.1016/j.cca.2013.09.050" @default.
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