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- W2006520336 abstract "Bacterial persistence is characterized by the ability of a subpopulation within bacterial cultures to survive exposure to antibiotics and other lethal treatments. The surviving persisters are not the result of genetic changes but represent epigenetic variants that are in a physiological state where growth is inhibited. Since characterization of persisters has been performed mainly in Escherichia coli K-12, we sought to identify mechanisms of persistence in the pathogen Salmonella enterica serovar Typhimurium. Isolation of new highly persistent mutants revealed that the shpAB locus (Salmonella high persistence) imparted a 3- to 4-order-of-magnitude increase in survival after ampicillin exposure throughout its growth phase and protected the population against exposure to multiple antibiotics. Genetic characterization revealed that shpAB is a newly discovered toxin-antitoxin (TA) module. The high-persistence phenotype was attributed to a nonsense mutation in the 3′ end of the shpB gene encoding an antitoxin protein. Characteristic of other TA modules, shpAB is autoregulated, and high persistence depends on the Lon protease." @default.
- W2006520336 created "2016-06-24" @default.
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- W2006520336 creator A5033103532 @default.
- W2006520336 creator A5033908255 @default.
- W2006520336 creator A5053204850 @default.
- W2006520336 date "2012-11-30" @default.
- W2006520336 modified "2023-10-18" @default.
- W2006520336 title "Isolation of Highly Persistent Mutants of Salmonella enterica Serovar Typhimurium Reveals a New Toxin-Antitoxin Module" @default.
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- W2006520336 doi "https://doi.org/10.1128/jb.01397-12" @default.
- W2006520336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3562109" @default.
- W2006520336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23204462" @default.
- W2006520336 hasPublicationYear "2012" @default.
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