Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006525603> ?p ?o ?g. }
- W2006525603 endingPage "89" @default.
- W2006525603 startingPage "84" @default.
- W2006525603 abstract "Ferritin is a ubiquitous and specialised protein involved in the intracellular storage of iron; it is also present in serum and other biological fluids, although its secretion processes are still unclear. We here review evidence supporting the hypothesis that macrophages play a role in the production and secretion of extracellular ferritin, as well as evidence supporting a novel function as a signalling molecule and immune regulator. In particular, H-ferritin, which inhibits the proliferation of lymphoid and myeloid cells, may be regarded as a negative regulator of human and murine hematopoiesis. The idea that it also acts as a signalling protein has been supported by the cloning and characterisation of the specific H-ferritin receptor TIM-2, a member of the TIM gene family. A number of studies of the mouse TIM gene family indicate that this protein plays an important role in immune-mediated diseases. This last finding, together with the fact that ferritin acts as an immuno-suppressor, has allowed us to formulate hypotheses regarding the possible role of alterations of H-ferritin/TIM-2 binding/signalling in the pathogenesis of autoimmune diseases." @default.
- W2006525603 created "2016-06-24" @default.
- W2006525603 creator A5001560379 @default.
- W2006525603 creator A5026578077 @default.
- W2006525603 creator A5042209946 @default.
- W2006525603 creator A5065511179 @default.
- W2006525603 date "2008-02-01" @default.
- W2006525603 modified "2023-10-02" @default.
- W2006525603 title "New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity" @default.
- W2006525603 cites W1529254101 @default.
- W2006525603 cites W157738979 @default.
- W2006525603 cites W1969255934 @default.
- W2006525603 cites W1969296748 @default.
- W2006525603 cites W1971693959 @default.
- W2006525603 cites W1972034430 @default.
- W2006525603 cites W1973879517 @default.
- W2006525603 cites W1977067868 @default.
- W2006525603 cites W1979522978 @default.
- W2006525603 cites W1979990873 @default.
- W2006525603 cites W1987945462 @default.
- W2006525603 cites W1988141641 @default.
- W2006525603 cites W1997753515 @default.
- W2006525603 cites W2002176673 @default.
- W2006525603 cites W2002650691 @default.
- W2006525603 cites W2003971758 @default.
- W2006525603 cites W2006383772 @default.
- W2006525603 cites W2008552530 @default.
- W2006525603 cites W2020279046 @default.
- W2006525603 cites W2023819715 @default.
- W2006525603 cites W2025833890 @default.
- W2006525603 cites W2025878569 @default.
- W2006525603 cites W2026705357 @default.
- W2006525603 cites W2029133355 @default.
- W2006525603 cites W2048961365 @default.
- W2006525603 cites W2049220931 @default.
- W2006525603 cites W2051104655 @default.
- W2006525603 cites W2051310075 @default.
- W2006525603 cites W2053064965 @default.
- W2006525603 cites W2056360848 @default.
- W2006525603 cites W2057138726 @default.
- W2006525603 cites W2060817012 @default.
- W2006525603 cites W2064095927 @default.
- W2006525603 cites W2072159717 @default.
- W2006525603 cites W2075187391 @default.
- W2006525603 cites W2078822435 @default.
- W2006525603 cites W2081110690 @default.
- W2006525603 cites W2082545727 @default.
- W2006525603 cites W2086567353 @default.
- W2006525603 cites W2088480409 @default.
- W2006525603 cites W2089739740 @default.
- W2006525603 cites W2095125269 @default.
- W2006525603 cites W2105755716 @default.
- W2006525603 cites W2106229817 @default.
- W2006525603 cites W2115541385 @default.
- W2006525603 cites W2127797915 @default.
- W2006525603 cites W2139235644 @default.
- W2006525603 cites W2140159180 @default.
- W2006525603 cites W2147741625 @default.
- W2006525603 cites W2149729174 @default.
- W2006525603 cites W2166210236 @default.
- W2006525603 cites W2343162401 @default.
- W2006525603 cites W298438027 @default.
- W2006525603 cites W4229966142 @default.
- W2006525603 cites W4251907294 @default.
- W2006525603 doi "https://doi.org/10.1016/j.jaut.2007.11.003" @default.
- W2006525603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18191543" @default.
- W2006525603 hasPublicationYear "2008" @default.
- W2006525603 type Work @default.
- W2006525603 sameAs 2006525603 @default.
- W2006525603 citedByCount "220" @default.
- W2006525603 countsByYear W20065256032012 @default.
- W2006525603 countsByYear W20065256032013 @default.
- W2006525603 countsByYear W20065256032014 @default.
- W2006525603 countsByYear W20065256032015 @default.
- W2006525603 countsByYear W20065256032016 @default.
- W2006525603 countsByYear W20065256032017 @default.
- W2006525603 countsByYear W20065256032018 @default.
- W2006525603 countsByYear W20065256032019 @default.
- W2006525603 countsByYear W20065256032020 @default.
- W2006525603 countsByYear W20065256032021 @default.
- W2006525603 countsByYear W20065256032022 @default.
- W2006525603 countsByYear W20065256032023 @default.
- W2006525603 crossrefType "journal-article" @default.
- W2006525603 hasAuthorship W2006525603A5001560379 @default.
- W2006525603 hasAuthorship W2006525603A5026578077 @default.
- W2006525603 hasAuthorship W2006525603A5042209946 @default.
- W2006525603 hasAuthorship W2006525603A5065511179 @default.
- W2006525603 hasConcept C104317684 @default.
- W2006525603 hasConcept C203014093 @default.
- W2006525603 hasConcept C2778319317 @default.
- W2006525603 hasConcept C2779282312 @default.
- W2006525603 hasConcept C2780130043 @default.
- W2006525603 hasConcept C49039625 @default.
- W2006525603 hasConcept C54355233 @default.
- W2006525603 hasConcept C55493867 @default.
- W2006525603 hasConcept C6929976 @default.
- W2006525603 hasConcept C86803240 @default.
- W2006525603 hasConcept C8891405 @default.