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• W2006537215 abstract "Abstract The present study sought to determine, in more detail, the effects of an unselective and a selective adenosine A 2A receptor blockade on catalepsy induced by a blockade of dopamine D 1 or D 2 receptors in rats. The results demonstrated that systemic administration of the unselective A 1 /A 2 receptor antagonist, theophylline and the selective A 2A receptor antagonist, CSC potently reversed catalepsy induced by a systemic D 2 receptor blockade with raclopride or by a bilateral blockade of D 2 receptors in the caudate‐putamen (CPu) with S(–)sulpiride. Likewise, systemic administration of theophylline and CSC reversed catalepsy induced by a systemic D 1 receptor blockade with SCH23390; theophylline also counteracted catalepsy after an intra‐CPu D 1 receptor blockade with SCH23390. Intracerebral co‐microinfusions of the selective A 2A receptor antagonist, MSX‐3 together with a D 1 (SCH23390) or D 2 receptor [S(–) sulpiride] antagonist revealed that catalepsy due to intra‐CPu D 1 or D 2 receptor blockade can be potently reversed by an intra‐CPu A 2A receptor blockade. In conclusion, our results with systemic and intra‐CPu drug administration demonstrate that D 1 and D 2 receptor‐mediated catalepsy can both be reversed by a concomitant blockade of A 2A receptors. Our results implicate that the CPu is a critical neural substrate for antagonistic interactions of a D 1/ D 2 receptor blockade and an A 2A receptor blockade in control of motor activity. The present results provide further support for the view that A 2A receptor antagonists may be potential therapeutics for the treatment of Parkinson's disease." @default.
• W2006537215 created "2016-06-24" @default.
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• W2006537215 date "2001-10-01" @default.
• W2006537215 modified "2023-10-18" @default.
• W2006537215 title "Catalepsy induced by a blockade of dopamine D₁or D₂receptors was reversed by a concomitant blockade of adenosine A_2Areceptors in the caudate-putamen of rats" @default.
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• W2006537215 doi "https://doi.org/10.1046/j.0953-816x.2001.01759.x" @default.
• W2006537215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11703457" @default.
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