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• W2006542554 abstract "B cells arise via a precise developmental pathway. Goodnow and Beutler report that mice bearing mutations in Atp11c, which encodes a phosphatidylserine 'flippase', have defective B cell generation in the adult bone marrow. B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not. Here we describe two allelic X-linked mutations in mice that caused cell-intrinsic arrest of adult B lymphopoiesis. Mutant fetal liver progenitors generated B cells in situ but not in irradiated adult bone marrow, which emphasizes a necessity for the affected pathway only in the context of adult bone marrow. The causative mutations were ascribed to Atp11c, which encodes a P4-type ATPase with no previously described function. Our data establish an essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development." @default.
• W2006542554 created "2016-06-24" @default.
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• W2006542554 date "2011-03-20" @default.
• W2006542554 modified "2023-10-06" @default.
• W2006542554 title "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow" @default.
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• W2006542554 doi "https://doi.org/10.1038/ni.2012" @default.
• W2006542554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079768" @default.
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• W2006542554 hasPublicationYear "2011" @default.
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