FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006556475> ?p ?o ?g. }

• W2006556475 endingPage "295" @default.
• W2006556475 startingPage "290" @default.
• W2006556475 abstract "Background. Several studies investigated the association of histologic scores of donor kidney biopsies obtained before engraftment with posttransplant outcomes. Discrimination and goodness of fit of these scores, however, is low. Methods. Thus, we sought to identify and elucidate the performance of molecular rather than histologic markers for this purpose using whole genome gene expression microarray experiments. Results. We identified 80 unique differentially regulated genes in 82 samples, showing no histologic damage versus those with histologic damage, based on the Chronic Allograft Damage Index (CADI) and acute tubular injury. Main biological categories enriched with up-regulated genes in damaged tissue were “immunity and defense,” “cell communication,” or “apoptosis.” Interestingly, genes involved in cell structure, cell adhesion, and protein trafficking were specific for tubular atrophy. Histology (CADI score) explained only 14% of the variability of 1 year creatinine (adjusted R2 for panel-reactive antibodies, biopsy confirmed acute rejection, and sum of human leukocyte antigen mismatches) whereas a combination of three biomarkers without clinical covariables explained 28%. The three molecular markers are the NLR family, pyrin domain containing 2 (NLRP2), immunoglobulin J polypeptide, and the regulator of G-protein signaling 5. Conclusion. In summary, we identified biomarkers in transplant kidney biopsies, which are predictive for medium-term allograft function." @default.
• W2006556475 created "2016-06-24" @default.
• W2006556475 creator A5004917278 @default.
• W2006556475 creator A5019700420 @default.
• W2006556475 creator A5023641042 @default.
• W2006556475 creator A5057262840 @default.
• W2006556475 creator A5080158744 @default.
• W2006556475 creator A5082002615 @default.
• W2006556475 date "2009-01-27" @default.
• W2006556475 modified "2023-09-27" @default.
• W2006556475 title "Histogenomics: Association of Gene Expression Patterns With Histological Parameters in Kidney Biopsies" @default.
• W2006556475 cites W175134418 @default.
• W2006556475 cites W1976852910 @default.
• W2006556475 cites W1984392412 @default.
• W2006556475 cites W1986036049 @default.
• W2006556475 cites W1997436834 @default.
• W2006556475 cites W2003585849 @default.
• W2006556475 cites W2012516711 @default.
• W2006556475 cites W2026226636 @default.
• W2006556475 cites W2027774428 @default.
• W2006556475 cites W2042001339 @default.
• W2006556475 cites W2044514479 @default.
• W2006556475 cites W2047256287 @default.
• W2006556475 cites W2048111761 @default.
• W2006556475 cites W2058852263 @default.
• W2006556475 cites W2065448696 @default.
• W2006556475 cites W2068751306 @default.
• W2006556475 cites W2075528627 @default.
• W2006556475 cites W2080944281 @default.
• W2006556475 cites W2092797088 @default.
• W2006556475 cites W2096863518 @default.
• W2006556475 cites W2097255042 @default.
• W2006556475 cites W2098773501 @default.
• W2006556475 cites W2114358746 @default.
• W2006556475 cites W2120865735 @default.
• W2006556475 cites W2123036912 @default.
• W2006556475 cites W2123060905 @default.
• W2006556475 cites W2123232514 @default.
• W2006556475 cites W2124265407 @default.
• W2006556475 cites W2136746722 @default.
• W2006556475 cites W2144014661 @default.
• W2006556475 cites W2159675211 @default.
• W2006556475 cites W2160697532 @default.
• W2006556475 cites W2168223461 @default.
• W2006556475 cites W45534775 @default.
• W2006556475 doi "https://doi.org/10.1097/tp.0b013e318191b4c0" @default.
• W2006556475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19155987" @default.
• W2006556475 hasPublicationYear "2009" @default.
• W2006556475 type Work @default.
• W2006556475 sameAs 2006556475 @default.
• W2006556475 citedByCount "37" @default.
• W2006556475 countsByYear W20065564752012 @default.
• W2006556475 countsByYear W20065564752013 @default.
• W2006556475 countsByYear W20065564752014 @default.
• W2006556475 countsByYear W20065564752015 @default.
• W2006556475 countsByYear W20065564752016 @default.
• W2006556475 countsByYear W20065564752017 @default.
• W2006556475 countsByYear W20065564752018 @default.
• W2006556475 countsByYear W20065564752019 @default.
• W2006556475 countsByYear W20065564752021 @default.
• W2006556475 countsByYear W20065564752022 @default.
• W2006556475 crossrefType "journal-article" @default.
• W2006556475 hasAuthorship W2006556475A5004917278 @default.
• W2006556475 hasAuthorship W2006556475A5019700420 @default.
• W2006556475 hasAuthorship W2006556475A5023641042 @default.
• W2006556475 hasAuthorship W2006556475A5057262840 @default.
• W2006556475 hasAuthorship W2006556475A5080158744 @default.
• W2006556475 hasAuthorship W2006556475A5082002615 @default.
• W2006556475 hasBestOaLocation W20065564751 @default.
• W2006556475 hasConcept C104317684 @default.
• W2006556475 hasConcept C142724271 @default.
• W2006556475 hasConcept C150194340 @default.
• W2006556475 hasConcept C159654299 @default.
• W2006556475 hasConcept C186836561 @default.
• W2006556475 hasConcept C203014093 @default.
• W2006556475 hasConcept C204232928 @default.
• W2006556475 hasConcept C2775934546 @default.
• W2006556475 hasConcept C2780091579 @default.
• W2006556475 hasConcept C54355233 @default.
• W2006556475 hasConcept C57742111 @default.
• W2006556475 hasConcept C71924100 @default.
• W2006556475 hasConcept C86803240 @default.
• W2006556475 hasConceptScore W2006556475C104317684 @default.
• W2006556475 hasConceptScore W2006556475C142724271 @default.
• W2006556475 hasConceptScore W2006556475C150194340 @default.
• W2006556475 hasConceptScore W2006556475C159654299 @default.
• W2006556475 hasConceptScore W2006556475C186836561 @default.
• W2006556475 hasConceptScore W2006556475C203014093 @default.
• W2006556475 hasConceptScore W2006556475C204232928 @default.
• W2006556475 hasConceptScore W2006556475C2775934546 @default.
• W2006556475 hasConceptScore W2006556475C2780091579 @default.
• W2006556475 hasConceptScore W2006556475C54355233 @default.
• W2006556475 hasConceptScore W2006556475C57742111 @default.
• W2006556475 hasConceptScore W2006556475C71924100 @default.
• W2006556475 hasConceptScore W2006556475C86803240 @default.
• W2006556475 hasIssue "2" @default.
• W2006556475 hasLocation W20065564751 @default.
• W2006556475 hasLocation W20065564752 @default.

• next