Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006558753> ?p ?o ?g. }
- W2006558753 endingPage "879" @default.
- W2006558753 startingPage "865" @default.
- W2006558753 abstract "To study the regulation of the human beta-interferon (beta-IFN) gene by poly(I)-poly(C), we analyzed the expression of deletion mutants of the cloned gene introduced into mouse cells on a new bovine papilloma virus (BPV) vector. In stable cell lines transformed by a BPV-IFN plasmid containing the beta-IFN structural gene with 210 bp of DNA to the 5' side of its mRNA cap site (denoted -210), human beta-IFN mRNA is induced approximately 400-fold by poly(I)-poly(C), and reproducible levels of expression are observed for independent cell lines. Our studies indicate that there are two distinct regulatory regions adjacent to the gene, located between -77 and -19, and between -210 and -107. The -77 to -19 region is required for constitutive and induced IFN gene expression, and both are drastically reduced by deletion to -73. When sequences between -210 and -107 are deleted, the constitutive level of IFN gene expression is increased 5- to 10-fold, while induced expression is essentially unaffected. Deletion of the -210 to -107 region also alters the kinetics of induction of the gene." @default.
- W2006558753 created "2016-06-24" @default.
- W2006558753 creator A5028206869 @default.
- W2006558753 creator A5028430067 @default.
- W2006558753 creator A5091116725 @default.
- W2006558753 date "1983-10-01" @default.
- W2006558753 modified "2023-10-10" @default.
- W2006558753 title "Identification of two distinct regulatory regions adjacent to the human β-interferon gene" @default.
- W2006558753 cites W1492588940 @default.
- W2006558753 cites W1557353187 @default.
- W2006558753 cites W1558516755 @default.
- W2006558753 cites W1573149714 @default.
- W2006558753 cites W1882869125 @default.
- W2006558753 cites W1967446284 @default.
- W2006558753 cites W1969600436 @default.
- W2006558753 cites W1971677635 @default.
- W2006558753 cites W1976491544 @default.
- W2006558753 cites W1979835151 @default.
- W2006558753 cites W1989313376 @default.
- W2006558753 cites W1994949898 @default.
- W2006558753 cites W2001004224 @default.
- W2006558753 cites W2003004828 @default.
- W2006558753 cites W2006434949 @default.
- W2006558753 cites W2011655388 @default.
- W2006558753 cites W2013891685 @default.
- W2006558753 cites W2024691096 @default.
- W2006558753 cites W2027411626 @default.
- W2006558753 cites W2046844890 @default.
- W2006558753 cites W2053105866 @default.
- W2006558753 cites W2054073262 @default.
- W2006558753 cites W2056618475 @default.
- W2006558753 cites W2057944550 @default.
- W2006558753 cites W2060333964 @default.
- W2006558753 cites W2070119139 @default.
- W2006558753 cites W2076118869 @default.
- W2006558753 cites W2076427033 @default.
- W2006558753 cites W2080097746 @default.
- W2006558753 cites W2083910110 @default.
- W2006558753 cites W2091065342 @default.
- W2006558753 cites W2091328653 @default.
- W2006558753 cites W2094470986 @default.
- W2006558753 cites W2104855527 @default.
- W2006558753 cites W2112834292 @default.
- W2006558753 cites W2114694071 @default.
- W2006558753 cites W2125633837 @default.
- W2006558753 cites W2147593914 @default.
- W2006558753 cites W2158290831 @default.
- W2006558753 cites W2166256336 @default.
- W2006558753 cites W2274575567 @default.
- W2006558753 doi "https://doi.org/10.1016/0092-8674(83)90544-5" @default.
- W2006558753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6313211" @default.
- W2006558753 hasPublicationYear "1983" @default.
- W2006558753 type Work @default.
- W2006558753 sameAs 2006558753 @default.
- W2006558753 citedByCount "1062" @default.
- W2006558753 countsByYear W20065587532012 @default.
- W2006558753 countsByYear W20065587532013 @default.
- W2006558753 countsByYear W20065587532014 @default.
- W2006558753 countsByYear W20065587532017 @default.
- W2006558753 countsByYear W20065587532018 @default.
- W2006558753 countsByYear W20065587532019 @default.
- W2006558753 countsByYear W20065587532020 @default.
- W2006558753 countsByYear W20065587532021 @default.
- W2006558753 countsByYear W20065587532023 @default.
- W2006558753 crossrefType "journal-article" @default.
- W2006558753 hasAuthorship W2006558753A5028206869 @default.
- W2006558753 hasAuthorship W2006558753A5028430067 @default.
- W2006558753 hasAuthorship W2006558753A5091116725 @default.
- W2006558753 hasConcept C104317684 @default.
- W2006558753 hasConcept C105580179 @default.
- W2006558753 hasConcept C143065580 @default.
- W2006558753 hasConcept C150194340 @default.
- W2006558753 hasConcept C153911025 @default.
- W2006558753 hasConcept C165864922 @default.
- W2006558753 hasConcept C21592294 @default.
- W2006558753 hasConcept C22744801 @default.
- W2006558753 hasConcept C2776178377 @default.
- W2006558753 hasConcept C54355233 @default.
- W2006558753 hasConcept C86803240 @default.
- W2006558753 hasConceptScore W2006558753C104317684 @default.
- W2006558753 hasConceptScore W2006558753C105580179 @default.
- W2006558753 hasConceptScore W2006558753C143065580 @default.
- W2006558753 hasConceptScore W2006558753C150194340 @default.
- W2006558753 hasConceptScore W2006558753C153911025 @default.
- W2006558753 hasConceptScore W2006558753C165864922 @default.
- W2006558753 hasConceptScore W2006558753C21592294 @default.
- W2006558753 hasConceptScore W2006558753C22744801 @default.
- W2006558753 hasConceptScore W2006558753C2776178377 @default.
- W2006558753 hasConceptScore W2006558753C54355233 @default.
- W2006558753 hasConceptScore W2006558753C86803240 @default.
- W2006558753 hasIssue "3" @default.
- W2006558753 hasLocation W20065587531 @default.
- W2006558753 hasLocation W20065587532 @default.
- W2006558753 hasOpenAccess W2006558753 @default.
- W2006558753 hasPrimaryLocation W20065587531 @default.
- W2006558753 hasRelatedWork W1847045739 @default.
- W2006558753 hasRelatedWork W1988612397 @default.
- W2006558753 hasRelatedWork W2043274041 @default.