FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006582029> ?p ?o ?g. }

• W2006582029 endingPage "834" @default.
• W2006582029 startingPage "826" @default.
• W2006582029 abstract "Exposure to high cortisol concentration can injure the developing brain, possibly via an excitotoxic mechanism involving glutamate (Glu). The present study tested the hypothesis that chronic prenatal ethanol exposure (CPEE) activates the foetal hypothalamic‐pituitary‐adrenal axis to produce high cortisol exposure in the foetal compartment and alters sensitivity to glucocorticoid‐induced Glu release in the foetal hippocampus. Pregnant guinea pigs received daily oral administration of ethanol (4 g/kg maternal body weight/day) or isocaloric‐sucrose/pair‐feeding from gestational day (GD) 2 until GD 63 (term, approximately GD 68) at which time they were euthanised, 1 h after their final treatment. Adrenocorticotrophic hormone (ACTH) and cortisol concentrations were determined in foetal plasma. Basal and electrically stimulated Glu and γ‐aminobutyric acid (GABA) efflux in the presence or absence of dexamethasone (DEX), a selective glucocorticoid‐receptor agonist, were determined ex vivo in foetal hippocampal slices. Glucocorticoid receptor (GR), mineralocorticoid receptor (MR) and N ‐methyl‐ d ‐aspartate (NMDA) receptor NR1 subunit mRNA expression were determined in situ in the hippocampus and dentate gyrus. In the near‐term foetus, CPEE increased foetal plasma ACTH and cortisol concentrations. Electrically stimulated glutamate, but not GABA, release was increased in CPEE foetal hippocampal slices. Low DEX concentration (0.3 µM) decreased stimulated glutamate, but not GABA, release in both CPEE and control foetal hippocampal slices. High DEX concentration (3.0 µ M ) increased basal release of Glu, but not GABA, in CPEE foetal hippocampal slices. GR, but not MR, mRNA expression was elevated in the hippocampus and dentate gyrus, whereas NR1 mRNA expression was increased in the CA1 and CA3 fields of the foetal hippocampus. These data demonstrate that CPEE increases high glucocorticoid concentration‐induced Glu release in the foetal hippocampus, presumably as a consequence of increased GR expression. These effects of CPEE, coupled with increased glutamate release and increased NMDA receptor expression, may predispose the near‐term foetal hippocampus to GR and Glu‐NMDA receptor‐mediated neurodevelopmental toxicity." @default.
• W2006582029 created "2016-06-24" @default.
• W2006582029 creator A5033280558 @default.
• W2006582029 creator A5037762972 @default.
• W2006582029 creator A5067824015 @default.
• W2006582029 creator A5071397090 @default.
• W2006582029 creator A5087502351 @default.
• W2006582029 date "2006-08-14" @default.
• W2006582029 modified "2023-10-15" @default.
• W2006582029 title "Chronic Prenatal Ethanol Exposure Increases Glucocorticoid-Induced Glutamate Release in the Hippocampus of the Near-Term Foetal Guinea Pig" @default.
• W2006582029 cites W1496119708 @default.
• W2006582029 cites W1547061295 @default.
• W2006582029 cites W1825161527 @default.
• W2006582029 cites W1843854943 @default.
• W2006582029 cites W1963599779 @default.
• W2006582029 cites W1967793239 @default.
• W2006582029 cites W1968341955 @default.
• W2006582029 cites W1976372065 @default.
• W2006582029 cites W1992638308 @default.
• W2006582029 cites W1996981116 @default.
• W2006582029 cites W1998617356 @default.
• W2006582029 cites W1998774655 @default.
• W2006582029 cites W1999391547 @default.
• W2006582029 cites W2000956334 @default.
• W2006582029 cites W2001688956 @default.
• W2006582029 cites W2009050469 @default.
• W2006582029 cites W2009448378 @default.
• W2006582029 cites W2010584142 @default.
• W2006582029 cites W2012522218 @default.
• W2006582029 cites W2013266397 @default.
• W2006582029 cites W2015497140 @default.
• W2006582029 cites W2017112724 @default.
• W2006582029 cites W2019175367 @default.
• W2006582029 cites W2024566047 @default.
• W2006582029 cites W2024741715 @default.
• W2006582029 cites W2027896083 @default.
• W2006582029 cites W2028201307 @default.
• W2006582029 cites W2029330170 @default.
• W2006582029 cites W2029602665 @default.
• W2006582029 cites W2029985888 @default.
• W2006582029 cites W2032448810 @default.
• W2006582029 cites W2040761658 @default.
• W2006582029 cites W2046718457 @default.
• W2006582029 cites W2055258155 @default.
• W2006582029 cites W2055350155 @default.
• W2006582029 cites W2059243325 @default.
• W2006582029 cites W2059936431 @default.
• W2006582029 cites W2062403124 @default.
• W2006582029 cites W2064552342 @default.
• W2006582029 cites W2067232233 @default.
• W2006582029 cites W2073103104 @default.
• W2006582029 cites W2075353403 @default.
• W2006582029 cites W2080131125 @default.
• W2006582029 cites W2081247087 @default.
• W2006582029 cites W2084130070 @default.
• W2006582029 cites W2085628837 @default.
• W2006582029 cites W2087525455 @default.
• W2006582029 cites W2088547451 @default.
• W2006582029 cites W2090910729 @default.
• W2006582029 cites W2109004721 @default.
• W2006582029 cites W2116932437 @default.
• W2006582029 cites W2125496328 @default.
• W2006582029 cites W2132902482 @default.
• W2006582029 cites W2148986317 @default.
• W2006582029 cites W2159223986 @default.
• W2006582029 cites W2159637414 @default.
• W2006582029 cites W2160282214 @default.
• W2006582029 cites W2163015424 @default.
• W2006582029 cites W2163211206 @default.
• W2006582029 cites W2165802543 @default.
• W2006582029 cites W2166717536 @default.
• W2006582029 cites W3139399376 @default.
• W2006582029 cites W4234397780 @default.
• W2006582029 cites W4237348831 @default.
• W2006582029 cites W4248210057 @default.
• W2006582029 doi "https://doi.org/10.1111/j.1365-2826.2006.01479.x" @default.
• W2006582029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17026532" @default.
• W2006582029 hasPublicationYear "2006" @default.
• W2006582029 type Work @default.
• W2006582029 sameAs 2006582029 @default.
• W2006582029 citedByCount "29" @default.
• W2006582029 countsByYear W20065820292012 @default.
• W2006582029 countsByYear W20065820292013 @default.
• W2006582029 countsByYear W20065820292014 @default.
• W2006582029 countsByYear W20065820292015 @default.
• W2006582029 countsByYear W20065820292016 @default.
• W2006582029 countsByYear W20065820292018 @default.
• W2006582029 countsByYear W20065820292023 @default.
• W2006582029 crossrefType "journal-article" @default.
• W2006582029 hasAuthorship W2006582029A5033280558 @default.
• W2006582029 hasAuthorship W2006582029A5037762972 @default.
• W2006582029 hasAuthorship W2006582029A5067824015 @default.
• W2006582029 hasAuthorship W2006582029A5071397090 @default.
• W2006582029 hasAuthorship W2006582029A5087502351 @default.
• W2006582029 hasConcept C126322002 @default.
• W2006582029 hasConcept C134018914 @default.
• W2006582029 hasConcept C148762608 @default.
• W2006582029 hasConcept C170493617 @default.

• next