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• W2006605576 abstract "Soluble guanylate cyclase, a heterodimer consisting of an alpha- and a heme-containing beta-subunit, is the major receptor for the biological messenger nitric oxide (NO) and is involved in various signal transduction pathways. The heme moiety of the enzyme is bound between the axial heme ligand histidine(105) and the recently identified counterparts of the heme propionic acids, tyrosine(135) and arginine(139). The latter residues together with an invariant serine(137) form the unique heme binding motif Y-x-S-x-R. In this work, we show that replacement of the serine(137) with alanine destabilizes the binding of the heme moiety and impairs NO-mediated soluble guanylate cyclase activation." @default.
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• W2006605576 date "2005-04-01" @default.
• W2006605576 modified "2023-10-13" @default.
• W2006605576 title "Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase" @default.
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• W2006605576 doi "https://doi.org/10.1016/j.ejphar.2005.02.046" @default.
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