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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006607302> ?p ?o ?g. }

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• W2006607302 abstract "Recordings have been made of changes in intracellular calcium ion concentration ([Ca2+]i) that can be attributed to the operation of an electrogenic, voltage-dependent sodium-calcium (Na-Ca) exchanger in mammalian heart cells. Guinea pig ventricular myocytes under voltage clamp were perfused internally with fura-2, a fluorescent Ca2+-indicator, and changes in [Ca2+]i and membrane current that resulted from Na-Ca exchange were identified through the use of various organic channel blockers and impermeant ions. Depolarization of cells elicited slow increases in [Ca2+]i, with the maximum increase depending on internal [Na+], external [Ca2+], and membrane voltage. Repolarization was associated with net Ca2+ efflux and a decline in the inward current that developed instantaneously upon repolarization. The relation between [Ca2+]i and current was linear, and the slope was made steeper by hyperpolarization." @default.
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• W2006607302 date "1987-12-18" @default.
• W2006607302 modified "2023-09-27" @default.
• W2006607302 title "Sodium-Calcium Exchange in Heart: Membrane Currents and Changes in [Ca ²⁺ ] _i" @default.
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• W2006607302 doi "https://doi.org/10.1126/science.3686010" @default.
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