FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006610513> ?p ?o ?g. }

• W2006610513 endingPage "481" @default.
• W2006610513 startingPage "478" @default.
• W2006610513 abstract "1. We studied the effect of the new compound trans-[RuCl([15]aneN(4))NO](2+) (15-ane) in denuded aortic rings of two kidney (2K) normotensive and two kidney, one clip (2K-1C) hypertensive rats. 2. The compound 15-ane releases nitric oxide (NO) when reduced by a catecholamine (noradrenaline). 3. Oxyhemoglobin (HbO(2)), an NO scavenger, completely abolished the effect of 15-ane in both 2K and 2K-1C rats, indicating that the relaxation is really due to NO release. 4. We tested the hypothesis that an impairment of K(+) channels plays an important role in the vasodilation induced by 15-ane. 5. The selective inhibitor of soluble guanylyl-cyclase, namely 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ; 1 micromol/L) reduced the relaxation induced by 15-ane. In 2K-1C rat aortic rings, ODQ reduced the maximum effect (E(max)) of 15-ane, whereas in 2K rat aortic rings ODQ reduced E(max) and pD(2) values to 15-ane. 6. The selective K(+) channel blockers glibenclamide (blocks K(ATP); 3 micromol/L), 4-aminopyridine (blocks K(V); 1 mmol/L) and the small conductance K(Ca) channel blocker apamin (1 micromol/L) reduced E(max) and pD(2) values for 15-ane-induced relaxation responses of aortas from 2K rats. However, iberiotoxin, a blocker of large conductance K(Ca) channels, reduced only the E(max) to 15-ane. None of these K(+) channel blockers had any effect on the relaxation induced by 15-ane of aortas from 2K-1C rats. 7. These data indicate that an impaired functional activity of K(+) channels contributes to the deficient relaxation induced by the NO donor 15-ane in renal hypertensive 2K-1C rat aortas." @default.
• W2006610513 created "2016-06-24" @default.
• W2006610513 creator A5014725918 @default.
• W2006610513 creator A5039162834 @default.
• W2006610513 creator A5056776784 @default.
• W2006610513 creator A5080894267 @default.
• W2006610513 date "2005-04-22" @default.
• W2006610513 modified "2023-10-16" @default.
• W2006610513 title "DECREASED VASODILATION INDUCED BY A NEW NITRIC OXIDE DONOR IN TWO KIDNEY, ONE CLIP HYPERTENSIVE RATS IS DUE TO IMPAIRED K⁺ CHANNEL ACTIVATION" @default.
• W2006610513 cites W1966097855 @default.
• W2006610513 cites W1969210400 @default.
• W2006610513 cites W1973464565 @default.
• W2006610513 cites W1990670567 @default.
• W2006610513 cites W1999361409 @default.
• W2006610513 cites W2002634997 @default.
• W2006610513 cites W2019814232 @default.
• W2006610513 cites W2022950339 @default.
• W2006610513 cites W2033042373 @default.
• W2006610513 cites W2034769077 @default.
• W2006610513 cites W2045967492 @default.
• W2006610513 cites W2051031920 @default.
• W2006610513 cites W2054818418 @default.
• W2006610513 cites W2063503589 @default.
• W2006610513 cites W2076841438 @default.
• W2006610513 cites W2082988280 @default.
• W2006610513 cites W2094797078 @default.
• W2006610513 cites W2102447197 @default.
• W2006610513 cites W2120141875 @default.
• W2006610513 cites W2131719276 @default.
• W2006610513 cites W2139561911 @default.
• W2006610513 cites W2139637725 @default.
• W2006610513 cites W2167282126 @default.
• W2006610513 cites W2171905844 @default.
• W2006610513 cites W2172907597 @default.
• W2006610513 cites W2256724151 @default.
• W2006610513 cites W2312870032 @default.
• W2006610513 doi "https://doi.org/10.1111/j.1440-1681.2005.04215.x" @default.
• W2006610513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15854162" @default.
• W2006610513 hasPublicationYear "2005" @default.
• W2006610513 type Work @default.
• W2006610513 sameAs 2006610513 @default.
• W2006610513 citedByCount "46" @default.
• W2006610513 countsByYear W20066105132012 @default.
• W2006610513 countsByYear W20066105132013 @default.
• W2006610513 countsByYear W20066105132014 @default.
• W2006610513 countsByYear W20066105132015 @default.
• W2006610513 countsByYear W20066105132016 @default.
• W2006610513 countsByYear W20066105132017 @default.
• W2006610513 countsByYear W20066105132018 @default.
• W2006610513 countsByYear W20066105132020 @default.
• W2006610513 countsByYear W20066105132021 @default.
• W2006610513 countsByYear W20066105132022 @default.
• W2006610513 crossrefType "journal-article" @default.
• W2006610513 hasAuthorship W2006610513A5014725918 @default.
• W2006610513 hasAuthorship W2006610513A5039162834 @default.
• W2006610513 hasAuthorship W2006610513A5056776784 @default.
• W2006610513 hasAuthorship W2006610513A5080894267 @default.
• W2006610513 hasConcept C120770815 @default.
• W2006610513 hasConcept C126322002 @default.
• W2006610513 hasConcept C134018914 @default.
• W2006610513 hasConcept C153461711 @default.
• W2006610513 hasConcept C185592680 @default.
• W2006610513 hasConcept C2776919887 @default.
• W2006610513 hasConcept C2779411790 @default.
• W2006610513 hasConcept C2779768347 @default.
• W2006610513 hasConcept C2780419564 @default.
• W2006610513 hasConcept C519063684 @default.
• W2006610513 hasConcept C519581460 @default.
• W2006610513 hasConcept C555293320 @default.
• W2006610513 hasConcept C71924100 @default.
• W2006610513 hasConcept C83743174 @default.
• W2006610513 hasConceptScore W2006610513C120770815 @default.
• W2006610513 hasConceptScore W2006610513C126322002 @default.
• W2006610513 hasConceptScore W2006610513C134018914 @default.
• W2006610513 hasConceptScore W2006610513C153461711 @default.
• W2006610513 hasConceptScore W2006610513C185592680 @default.
• W2006610513 hasConceptScore W2006610513C2776919887 @default.
• W2006610513 hasConceptScore W2006610513C2779411790 @default.
• W2006610513 hasConceptScore W2006610513C2779768347 @default.
• W2006610513 hasConceptScore W2006610513C2780419564 @default.
• W2006610513 hasConceptScore W2006610513C519063684 @default.
• W2006610513 hasConceptScore W2006610513C519581460 @default.
• W2006610513 hasConceptScore W2006610513C555293320 @default.
• W2006610513 hasConceptScore W2006610513C71924100 @default.
• W2006610513 hasConceptScore W2006610513C83743174 @default.
• W2006610513 hasIssue "5-6" @default.
• W2006610513 hasLocation W20066105131 @default.
• W2006610513 hasLocation W20066105132 @default.
• W2006610513 hasOpenAccess W2006610513 @default.
• W2006610513 hasPrimaryLocation W20066105131 @default.
• W2006610513 hasRelatedWork W1987923412 @default.
• W2006610513 hasRelatedWork W1990217750 @default.
• W2006610513 hasRelatedWork W2001072936 @default.
• W2006610513 hasRelatedWork W2017123222 @default.
• W2006610513 hasRelatedWork W2046283757 @default.
• W2006610513 hasRelatedWork W2056682731 @default.
• W2006610513 hasRelatedWork W2068271157 @default.
• W2006610513 hasRelatedWork W2086683885 @default.

• next