Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006615722> ?p ?o ?g. }
- W2006615722 endingPage "25S" @default.
- W2006615722 startingPage "21S" @default.
- W2006615722 abstract "The transplantation of donor hematopoietic stem cells has been used successfully in numerous experimental settings to induce donor-specific tolerance. After appropriate host conditioning, hematopoietic stem-cell transplantation leads to a lasting state of donor macrochimerism that is associated with a robust form of tolerance. One of the key factors in the success of this approach is its reliance on intrathymic clonal deletion to ensure lifelong tolerization of newly developing T cells. Evidence for ongoing central deletion comes from studies following superantigen-reactive T cells and from experiments using mice transgenic for an alloreactive T-cell receptor. In protocols inducing tolerance through macrochimerism, the preexisting mature T-cell repertoire is controlled by either globally destroying all T cells before the hematopoietic cell transplantation or, in more recent models, by tolerizing it through co-stimulation blockade. The peripheral mechanisms induced by hematopoietic stem-cell transplantation and co-stimulation blockade include both extrathymic clonal deletion and the nondeletional mechanisms anergy, suppression, or both. In addition to these immunologic hurdles, a physiologic engraftment barrier has to be surmounted for the successful induction of mixed chimerism. This can be achieved by cytoreductive host treatment or by the infusion of high numbers of donor hematopoietic cells. A detailed delineation of the mechanisms responsible for tolerance induction after hematopoietic stem-cell transplantation is expected to help in the translation of these experimental protocols to clinical organ transplantation." @default.
- W2006615722 created "2016-06-24" @default.
- W2006615722 creator A5006544627 @default.
- W2006615722 creator A5020262838 @default.
- W2006615722 creator A5021627667 @default.
- W2006615722 creator A5045314207 @default.
- W2006615722 creator A5056359769 @default.
- W2006615722 creator A5082762917 @default.
- W2006615722 date "2003-05-01" @default.
- W2006615722 modified "2023-09-27" @default.
- W2006615722 title "Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral tolerance" @default.
- W2006615722 cites W11344094 @default.
- W2006615722 cites W1508026137 @default.
- W2006615722 cites W1532325696 @default.
- W2006615722 cites W1548356984 @default.
- W2006615722 cites W1967891950 @default.
- W2006615722 cites W1969797237 @default.
- W2006615722 cites W2003176999 @default.
- W2006615722 cites W2003657878 @default.
- W2006615722 cites W2009173904 @default.
- W2006615722 cites W2020934961 @default.
- W2006615722 cites W2033466930 @default.
- W2006615722 cites W2044486934 @default.
- W2006615722 cites W2056210319 @default.
- W2006615722 cites W2059616506 @default.
- W2006615722 cites W2064457820 @default.
- W2006615722 cites W2067773447 @default.
- W2006615722 cites W2100224612 @default.
- W2006615722 cites W2110176131 @default.
- W2006615722 cites W2148052826 @default.
- W2006615722 cites W2151817322 @default.
- W2006615722 cites W2158673452 @default.
- W2006615722 cites W2164035061 @default.
- W2006615722 cites W2167745011 @default.
- W2006615722 cites W2169095843 @default.
- W2006615722 cites W2170728825 @default.
- W2006615722 cites W2171060039 @default.
- W2006615722 cites W2375033169 @default.
- W2006615722 cites W2413131581 @default.
- W2006615722 cites W4253611909 @default.
- W2006615722 doi "https://doi.org/10.1097/01.tp.0000067947.90241.66" @default.
- W2006615722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12819486" @default.
- W2006615722 hasPublicationYear "2003" @default.
- W2006615722 type Work @default.
- W2006615722 sameAs 2006615722 @default.
- W2006615722 citedByCount "41" @default.
- W2006615722 countsByYear W20066157222012 @default.
- W2006615722 countsByYear W20066157222013 @default.
- W2006615722 countsByYear W20066157222014 @default.
- W2006615722 countsByYear W20066157222015 @default.
- W2006615722 countsByYear W20066157222016 @default.
- W2006615722 countsByYear W20066157222017 @default.
- W2006615722 countsByYear W20066157222018 @default.
- W2006615722 countsByYear W20066157222020 @default.
- W2006615722 countsByYear W20066157222021 @default.
- W2006615722 countsByYear W20066157222023 @default.
- W2006615722 crossrefType "journal-article" @default.
- W2006615722 hasAuthorship W2006615722A5006544627 @default.
- W2006615722 hasAuthorship W2006615722A5020262838 @default.
- W2006615722 hasAuthorship W2006615722A5021627667 @default.
- W2006615722 hasAuthorship W2006615722A5045314207 @default.
- W2006615722 hasAuthorship W2006615722A5056359769 @default.
- W2006615722 hasAuthorship W2006615722A5082762917 @default.
- W2006615722 hasBestOaLocation W20066157221 @default.
- W2006615722 hasConcept C109159458 @default.
- W2006615722 hasConcept C126322002 @default.
- W2006615722 hasConcept C19317047 @default.
- W2006615722 hasConcept C203014093 @default.
- W2006615722 hasConcept C2776090121 @default.
- W2006615722 hasConcept C2777016536 @default.
- W2006615722 hasConcept C2777408962 @default.
- W2006615722 hasConcept C2777702733 @default.
- W2006615722 hasConcept C2777868816 @default.
- W2006615722 hasConcept C2778086970 @default.
- W2006615722 hasConcept C28328180 @default.
- W2006615722 hasConcept C2911091166 @default.
- W2006615722 hasConcept C502942594 @default.
- W2006615722 hasConcept C71924100 @default.
- W2006615722 hasConcept C86803240 @default.
- W2006615722 hasConcept C8891405 @default.
- W2006615722 hasConcept C95444343 @default.
- W2006615722 hasConceptScore W2006615722C109159458 @default.
- W2006615722 hasConceptScore W2006615722C126322002 @default.
- W2006615722 hasConceptScore W2006615722C19317047 @default.
- W2006615722 hasConceptScore W2006615722C203014093 @default.
- W2006615722 hasConceptScore W2006615722C2776090121 @default.
- W2006615722 hasConceptScore W2006615722C2777016536 @default.
- W2006615722 hasConceptScore W2006615722C2777408962 @default.
- W2006615722 hasConceptScore W2006615722C2777702733 @default.
- W2006615722 hasConceptScore W2006615722C2777868816 @default.
- W2006615722 hasConceptScore W2006615722C2778086970 @default.
- W2006615722 hasConceptScore W2006615722C28328180 @default.
- W2006615722 hasConceptScore W2006615722C2911091166 @default.
- W2006615722 hasConceptScore W2006615722C502942594 @default.
- W2006615722 hasConceptScore W2006615722C71924100 @default.
- W2006615722 hasConceptScore W2006615722C86803240 @default.
- W2006615722 hasConceptScore W2006615722C8891405 @default.
- W2006615722 hasConceptScore W2006615722C95444343 @default.