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- W2006618445 abstract "A photonic lab on a chip (PhLOC), comprising a solid-state light emitter (SSLE) aligned with a biofunctionalized optofluidic multiple internal reflection (MIR) system, is presented. The SSLE is obtained by filling a microfluidic structure with a phenyltrimethoxysilane (PhTMOS) aqueous sol solution containing a fluorophore organic dye. After curing, the resulting xerogel solid structure retains the emitting properties of the fluorophore, which is evenly distributed in the xerogel matrix. Photostability studies demonstrate that after a total dose (at λ=365 nm) greater than 24 J cm−2, the xerogel emission decay is only 4.1%. To re-direct the emitted light, the SSLE includes two sets of air mirrors that surround the xerogel. Emission mapping of the SSLE demonstrates that alignment variations of 150 µm (between the SSLE and the external pumping light source) provide fluctuations in emitted light smaller than 5%. After this verification, the SSLE is monolithically implemented with a MIR, forming the PhLOC. Its performance is assessed by measuring quinolone yellow, obtaining a limit of detection (LOD) of (0.60±0.01) µM. Finally, the MIR is selectively biofunctionalized with horseradish peroxidase (HRP) for the detection of hydrogen peroxide (H2O2) target analyte, obtaining a LOD of (0.7±0.1) µM for H2O2, confirming, for the first time, that solid-state xerogel-based emitters can be massively implemented in biofunctionalized PhLOCs. A photonic lab on a chip that can be biofunctionalized and contains a solid-state light emitter has been made by a team in Spain and Germany. Sol-gel technology is used to fabricate the solid-state light emitter — a microfluidic structure is filled with an aqueous sol solution containing an organic fluorophore and the solution is then cured to produce a solid xerogel structure in which the fluorophore is evenly dispersed. Emitted light is redirected to an optofluidic multiple internal reflection element by two sets of air mirrors. As the fabrication process is monolithic and involves only a single photolithographic step, it is inexpensive and the components are inherently aligned. The researchers demonstrate the potential of the system for sensing by using it to detect quinoline yellow and, after biofunctionalizing the multiple internal reflection element, hydrogen peroxide." @default.
- W2006618445 created "2016-06-24" @default.
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- W2006618445 date "2015-04-10" @default.
- W2006618445 modified "2023-10-12" @default.
- W2006618445 title "Biofunctionalized all-polymer photonic lab on a chip with integrated solid-state light emitter" @default.
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- W2006618445 doi "https://doi.org/10.1038/lsa.2015.44" @default.
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