FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W200663457> ?p ?o ?g. }

• W200663457 endingPage "579" @default.
• W200663457 startingPage "573" @default.
• W200663457 abstract "A variety of agonists stimulate in hepatocytes a response that takes the shape of repetitive cytosolic free Ca2+ transients called Ca2+ oscillations. The shape of spikes and the pattern of oscillations in a given cell differ depending on the agonist of the phosphoinositide pathway that is applied. In this study, the response of individual rat hepatocytes to maximal stimulation by arginine vasopressin (AVP), phenylephrine and ADP was investigated by fluorescence microscopy and flash photolysis. Hepatocytes loaded with Ca2+-sensitive probes were stimulated with a first agonist to evoke a maximal response, and then a second agonist was added. When phenylephrine or ADP was used as the first agonist, AVP applied subsequently could elicit an additional response, which did not happen when AVP was first applied and phenylephrine or ADP was applied later. Cells microinjected with caged myo-inositol 1,4,5-trisphosphate (IP3) were challenged with the different agonists and, when a maximal response was obtained, photorelease of IP3 was triggered. Cells maximally stimulated with AVP did not respond to IP3 photorelease, whereas those stimulated with phenylephrine or ADP responded with a fast Ca2+ spike above the elevated steady-state level, which was followed by an undershoot. In contrast, with all three agonists, IP3 photorelease triggered at the top of an oscillatory Ca2+ transient was able to mobilize additional Ca2+. These experiments indicate that the differential response of cells to agonists is found not only during Ca2+ oscillations but also during maximal agonist stimulation and that potency and efficacy differences exist among agonists." @default.
• W200663457 created "2016-06-24" @default.
• W200663457 creator A5021208951 @default.
• W200663457 creator A5048087477 @default.
• W200663457 creator A5084404570 @default.
• W200663457 date "1997-12-01" @default.
• W200663457 modified "2023-10-18" @default.
• W200663457 title "Agonist-specific behaviour of the intracellular Ca2+ response in rat hepatocytes" @default.
• W200663457 cites W1492343139 @default.
• W200663457 cites W1515871965 @default.
• W200663457 cites W1516802713 @default.
• W200663457 cites W1557726811 @default.
• W200663457 cites W1673140014 @default.
• W200663457 cites W1749589053 @default.
• W200663457 cites W1903153740 @default.
• W200663457 cites W1923432172 @default.
• W200663457 cites W1930917734 @default.
• W200663457 cites W1933881094 @default.
• W200663457 cites W1977068570 @default.
• W200663457 cites W1996024251 @default.
• W200663457 cites W1997778815 @default.
• W200663457 cites W2000369964 @default.
• W200663457 cites W2013083469 @default.
• W200663457 cites W2028469352 @default.
• W200663457 cites W2035358198 @default.
• W200663457 cites W2049778578 @default.
• W200663457 cites W2080027694 @default.
• W200663457 cites W2083720193 @default.
• W200663457 cites W2084602470 @default.
• W200663457 cites W2092754551 @default.
• W200663457 cites W2093198515 @default.
• W200663457 cites W2112197155 @default.
• W200663457 cites W2112324969 @default.
• W200663457 cites W2141260882 @default.
• W200663457 cites W2176833444 @default.
• W200663457 cites W2232449214 @default.
• W200663457 cites W2336864014 @default.
• W200663457 cites W5462217 @default.
• W200663457 cites W9958541 @default.
• W200663457 doi "https://doi.org/10.1042/bj3280573" @default.
• W200663457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1218957" @default.
• W200663457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9371717" @default.
• W200663457 hasPublicationYear "1997" @default.
• W200663457 type Work @default.
• W200663457 sameAs 200663457 @default.
• W200663457 citedByCount "4" @default.
• W200663457 crossrefType "journal-article" @default.
• W200663457 hasAuthorship W200663457A5021208951 @default.
• W200663457 hasAuthorship W200663457A5048087477 @default.
• W200663457 hasAuthorship W200663457A5084404570 @default.
• W200663457 hasBestOaLocation W2006634572 @default.
• W200663457 hasConcept C12554922 @default.
• W200663457 hasConcept C126322002 @default.
• W200663457 hasConcept C134018914 @default.
• W200663457 hasConcept C170493617 @default.
• W200663457 hasConcept C181199279 @default.
• W200663457 hasConcept C185592680 @default.
• W200663457 hasConcept C24998067 @default.
• W200663457 hasConcept C2776370428 @default.
• W200663457 hasConcept C2777427919 @default.
• W200663457 hasConcept C2777952589 @default.
• W200663457 hasConcept C2778618036 @default.
• W200663457 hasConcept C2778938600 @default.
• W200663457 hasConcept C2781387506 @default.
• W200663457 hasConcept C55493867 @default.
• W200663457 hasConcept C71924100 @default.
• W200663457 hasConcept C79879829 @default.
• W200663457 hasConcept C84393581 @default.
• W200663457 hasConcept C86803240 @default.
• W200663457 hasConcept C98539663 @default.
• W200663457 hasConceptScore W200663457C12554922 @default.
• W200663457 hasConceptScore W200663457C126322002 @default.
• W200663457 hasConceptScore W200663457C134018914 @default.
• W200663457 hasConceptScore W200663457C170493617 @default.
• W200663457 hasConceptScore W200663457C181199279 @default.
• W200663457 hasConceptScore W200663457C185592680 @default.
• W200663457 hasConceptScore W200663457C24998067 @default.
• W200663457 hasConceptScore W200663457C2776370428 @default.
• W200663457 hasConceptScore W200663457C2777427919 @default.
• W200663457 hasConceptScore W200663457C2777952589 @default.
• W200663457 hasConceptScore W200663457C2778618036 @default.
• W200663457 hasConceptScore W200663457C2778938600 @default.
• W200663457 hasConceptScore W200663457C2781387506 @default.
• W200663457 hasConceptScore W200663457C55493867 @default.
• W200663457 hasConceptScore W200663457C71924100 @default.
• W200663457 hasConceptScore W200663457C79879829 @default.
• W200663457 hasConceptScore W200663457C84393581 @default.
• W200663457 hasConceptScore W200663457C86803240 @default.
• W200663457 hasConceptScore W200663457C98539663 @default.
• W200663457 hasIssue "2" @default.
• W200663457 hasLocation W2006634571 @default.
• W200663457 hasLocation W2006634572 @default.
• W200663457 hasLocation W2006634573 @default.
• W200663457 hasLocation W2006634574 @default.
• W200663457 hasOpenAccess W200663457 @default.
• W200663457 hasPrimaryLocation W2006634571 @default.
• W200663457 hasRelatedWork W1598622521 @default.
• W200663457 hasRelatedWork W1965151570 @default.

• next