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• W2006634706 abstract "1 The present study was aimed at examining the role of 5-HT3 receptors in basal and depolarization-evoked dopamine release from rat olfactory tubercle and striatal slices. [3H]-dopamine ([3H]-DA) release was measured in both brain regions and endogenous dopamine release from striatal slices was also studied. 2 The selective 5-HT3 receptor agonist 2-methyl-5-HT (0.5–10μm) produced a concentration-dependent increase in [3H]-DA efflux evoked by K+ (20 μm) from slices of rat olfactory tubercle. 1-Phenylbiguanide (PBG) and 5-HT also increased K+-evoked [3H]-DA efflux. 3 5-HT (1–100 μm) increased in a concentration-dependent manner basal [3H]-DA release from olfactory tubercle and striatal slices as well as endogenous DA release from striatal slices. The selective 5-HT3 receptor agonists 2-methyl-5-HT and 1-phenylbiguanide were weaker releasing agents. In all cases, the release was Ca2+ independent and tetrodotoxin insensitive. 4 5-HT3 receptor antagonists such as ondansetron, granisetron and tropisetron (0.2 μm) significantly blocked the enhanced K+-evoked [3H]-DA efflux from rat olfactory tubercle slices induced by 2-methyl-5-HT. A ten fold higher concentration of the 5-HT2 receptor antagonist ketanserin was ineffective. 5 Much higher concentrations, up to 50 μm, of the same 5-HT3 receptor antagonists did not block the increase in basal [3H]-DA release from striatal or olfactory tubercle slices induced by 5-HT or the release of endogenous DA induced by 5-HT from striatal slices. 6 The DA uptake blocker nomifensine (10 μm) did not modify the enhancement in K+-evoked [3H]-DA efflux from rat olfactory tubercle slices induced by 2-methyl-5-HT. However, both nomifensine and cocaine significantly blocked the increase in basal dopamine release, either tritiated or endogenous, induced by 5-HT. 7 These results indicate that 5-HT3 receptors only modulate DA release when the terminal fields of dopaminergic systems have been activated. In basal conditions, 5-HT3 receptor agonists enhance DA release through a carrier-mediated mechanism. This may be of therapeutic relevance for the possible use of 5-HT3 receptor antagonists under conditions of abnormal activation of the dopaminergic system." @default.
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• W2006634706 date "1994-11-01" @default.
• W2006634706 modified "2023-10-15" @default.
• W2006634706 title "Role of 5-HT3 receptors in basal and K+-evoked dopamine release from rat olfactory tubercle and striatal slices" @default.
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• W2006634706 doi "https://doi.org/10.1111/j.1476-5381.1994.tb17087.x" @default.
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