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• W2006635402 abstract "Important characteristics for ideal skin preparations include long-lasting antimicrobial efficacy and low potential for skin irritation.A total of 55 healthy adult subjects were enrolled to evaluate the antimicrobial effects of 3 test formulations applied to inguinal, abdominal, and antecubital sites at post-treatment time points of 30 seconds, 72 hours, and 7 days. To investigate skin irritation potential, the 3 formulations were tested in a 21-day repeat-insult patch test conducted on the skin of the backs of 23 healthy subjects.The mean log(10) reduction (MLR) at 7 days post-treatment produced by a 79% vol/vol ethanol containing 1% wt/vol chlorhexidine gluconate (1% CHG-EtOH) applied to abdominal sites was significantly superior to that produced by a 10% povidone-iodine solution (2.45 MLR vs 0.90 MLR; P < .05). The 1% CHG-EtOH and a 70% vol/vol isopropanol containing 2% wt/vol CHG (2% CHG-IPA) provided statistically equivalent persistence at 72 hours and 7 days post-treatment. The 1% CHG-EtOH had less skin irritation potential than the 2% CHG-IPA and the 10% povidone-iodine solution, although the differences were not statistically significant (P > .05).Considering its persistent effect and low skin irritation potential, the 1% CHG-EtOH preparation is expected to perform well in surgical site preparation to reduce the risk of surgery- and catheter-related bloodstream infection." @default.
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• W2006635402 date "2012-12-01" @default.
• W2006635402 modified "2023-09-26" @default.
• W2006635402 title "Evaluation with a focus on both the antimicrobial efficacy and cumulative skin irritation potential of chlorhexidine gluconate alcohol–containing preoperative skin preparations" @default.
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• W2006635402 doi "https://doi.org/10.1016/j.ajic.2012.04.323" @default.
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