FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006643119> ?p ?o ?g. }

• W2006643119 endingPage "263" @default.
• W2006643119 startingPage "253" @default.
• W2006643119 abstract "Experimental Autoimmune Encephalomyelitis (EAE) is the most commonly used animal model for Multiple Sclerosis (MScl). CSF metabolomics in an acute EAE rat model was investigated using targetted LC–MS and GC–MS. Acute EAE in Lewis rats was induced by co-injection of Myelin Basic Protein with Complete Freund’s Adjuvant. CSF samples were collected at two time points: 10 days after inoculation, which was during the onset of the disease, and 14 days after inoculation, which was during the peak of the disease. The obtained metabolite profiles from the two time points of EAE development show profound differences between onset and the peak of the disease, suggesting significant changes in CNS metabolism over the course of MBP-induced neuroinflammation. Around the onset of EAE the metabolome profile shows significant decreases in arginine, alanine and branched amino acid levels, relative to controls. At the peak of the disease, significant increases in concentrations of multiple metabolites are observed, including glutamine, O-phosphoethanolamine, branched-chain amino acids and putrescine. Observed changes in metabolite levels suggest profound changes in CNS metabolism over the course of EAE. Affected pathways include nitric oxide synthesis, altered energy metabolism, polyamine synthesis and levels of endogenous antioxidants." @default.
• W2006643119 created "2016-06-24" @default.
• W2006643119 creator A5011648806 @default.
• W2006643119 creator A5019724319 @default.
• W2006643119 creator A5022803982 @default.
• W2006643119 creator A5039988625 @default.
• W2006643119 creator A5042878041 @default.
• W2006643119 creator A5044095101 @default.
• W2006643119 creator A5050140666 @default.
• W2006643119 creator A5067643421 @default.
• W2006643119 creator A5075330647 @default.
• W2006643119 creator A5076255429 @default.
• W2006643119 creator A5079069511 @default.
• W2006643119 creator A5081421924 @default.
• W2006643119 creator A5083318797 @default.
• W2006643119 date "2011-04-16" @default.
• W2006643119 modified "2023-10-10" @default.
• W2006643119 title "Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis" @default.
• W2006643119 cites W1680162993 @default.
• W2006643119 cites W1846277680 @default.
• W2006643119 cites W1966203257 @default.
• W2006643119 cites W1969076867 @default.
• W2006643119 cites W1977472501 @default.
• W2006643119 cites W1982084620 @default.
• W2006643119 cites W1984089779 @default.
• W2006643119 cites W1984704134 @default.
• W2006643119 cites W1989927249 @default.
• W2006643119 cites W1990581744 @default.
• W2006643119 cites W2003414488 @default.
• W2006643119 cites W2003853223 @default.
• W2006643119 cites W2004301401 @default.
• W2006643119 cites W2011814478 @default.
• W2006643119 cites W2012682323 @default.
• W2006643119 cites W2015301575 @default.
• W2006643119 cites W2015583679 @default.
• W2006643119 cites W2018076136 @default.
• W2006643119 cites W2032989272 @default.
• W2006643119 cites W2045330664 @default.
• W2006643119 cites W2052644415 @default.
• W2006643119 cites W2053585116 @default.
• W2006643119 cites W2060437747 @default.
• W2006643119 cites W2075655729 @default.
• W2006643119 cites W2090862497 @default.
• W2006643119 cites W2092707862 @default.
• W2006643119 cites W2099232685 @default.
• W2006643119 cites W2118855202 @default.
• W2006643119 cites W2118925636 @default.
• W2006643119 cites W2119021947 @default.
• W2006643119 cites W2133010666 @default.
• W2006643119 cites W2151018619 @default.
• W2006643119 cites W2162521648 @default.
• W2006643119 cites W2489642619 @default.
• W2006643119 cites W2492008729 @default.
• W2006643119 cites W2502759836 @default.
• W2006643119 cites W2504825279 @default.
• W2006643119 cites W4210979710 @default.
• W2006643119 doi "https://doi.org/10.1007/s11306-011-0306-3" @default.
• W2006643119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3291832" @default.
• W2006643119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22448154" @default.
• W2006643119 hasPublicationYear "2011" @default.
• W2006643119 type Work @default.
• W2006643119 sameAs 2006643119 @default.
• W2006643119 citedByCount "107" @default.
• W2006643119 countsByYear W20066431192012 @default.
• W2006643119 countsByYear W20066431192013 @default.
• W2006643119 countsByYear W20066431192014 @default.
• W2006643119 countsByYear W20066431192015 @default.
• W2006643119 countsByYear W20066431192016 @default.
• W2006643119 countsByYear W20066431192017 @default.
• W2006643119 countsByYear W20066431192018 @default.
• W2006643119 countsByYear W20066431192019 @default.
• W2006643119 countsByYear W20066431192020 @default.
• W2006643119 countsByYear W20066431192021 @default.
• W2006643119 countsByYear W20066431192022 @default.
• W2006643119 countsByYear W20066431192023 @default.
• W2006643119 crossrefType "journal-article" @default.
• W2006643119 hasAuthorship W2006643119A5011648806 @default.
• W2006643119 hasAuthorship W2006643119A5019724319 @default.
• W2006643119 hasAuthorship W2006643119A5022803982 @default.
• W2006643119 hasAuthorship W2006643119A5039988625 @default.
• W2006643119 hasAuthorship W2006643119A5042878041 @default.
• W2006643119 hasAuthorship W2006643119A5044095101 @default.
• W2006643119 hasAuthorship W2006643119A5050140666 @default.
• W2006643119 hasAuthorship W2006643119A5067643421 @default.
• W2006643119 hasAuthorship W2006643119A5075330647 @default.
• W2006643119 hasAuthorship W2006643119A5076255429 @default.
• W2006643119 hasAuthorship W2006643119A5079069511 @default.
• W2006643119 hasAuthorship W2006643119A5081421924 @default.
• W2006643119 hasAuthorship W2006643119A5083318797 @default.
• W2006643119 hasBestOaLocation W20066431191 @default.
• W2006643119 hasConcept C126322002 @default.
• W2006643119 hasConcept C134018914 @default.
• W2006643119 hasConcept C135870905 @default.
• W2006643119 hasConcept C185592680 @default.
• W2006643119 hasConcept C203014093 @default.
• W2006643119 hasConcept C21565614 @default.
• W2006643119 hasConcept C2777468819 @default.
• W2006643119 hasConcept C2777477808 @default.

• next