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- W2006644595 abstract "Blood pressure (BP) control at recently established goals of <130/80 mm Hg is often difficult to achieve in diabetic patients. This work examines the effect of pioglitazone on 24‐hour ambulatory BP monitoring in patients with type 2 diabetes and difficult‐to‐control hypertension. Twenty‐seven participants with difficult‐to‐control hypertension (defined as ambulatory BP monitoring ≥125/75 mm Hg) taking antihypertensive medications (mean, 4.1±0.8 drugs) were enrolled in an open, prospective, blinded end point study of add‐on therapy with pioglitazone 30 to 45 mg for 20 weeks. After 20 weeks of treatment, 24‐hour ambulatory BP monitoring showed significant reductions (from 144±13 to 136±16 mm Hg systolic BP and from 79±9 to 76±10 mm Hg diastolic BP [ P =.001]). Treatment was also associated with improvements in insulin sensitivity and glycemic and lipid profile. These findings suggest that pioglitazone could be a therapeutic option in diabetics who still have elevated BP values in spite of receiving treatment with at least 3 antihypertensive drugs." @default.
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- W2006644595 date "2007-07-01" @default.
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- W2006644595 title "Pioglitazone Decreases Ambulatory Blood Pressure in Type 2 Diabetics With Difficult‐to‐Control Hypertension" @default.
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- W2006644595 doi "https://doi.org/10.1111/j.1524-6175.2007.06694.x" @default.
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