Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006647527> ?p ?o ?g. }
- W2006647527 endingPage "499" @default.
- W2006647527 startingPage "485" @default.
- W2006647527 abstract "The development of cardiopulmonary bypass (CPB) has been one of the greatest technical advancements in cardiovascular medicine. With heparin anticoagulation, this device can safely replace the circulatory and gas-exchanging functions of the heart and lung, facilitating complex cardiac operations. Limitations still exist however, related to blood reactions at the biomaterial surface, such as cell activation, inflammation and low-grade thrombosis. In this brief review, the thought processes which paralleled the development of CPB biocompatible surfaces such as heparin-coating, will be explored, as well as current theories on the suspected mechanisms by which heparin-coated surfaces act as an anti-inflammatory device during CPB. Results with new surfaces for CPB designed to capitalize on superior protein adsorption properties, such as surface modifying additive (SMA) and poly (2-methoxyethylacrylate) (PMEA), will also be described. Finally, the significance of biomaterial-independent blood activation will be discussed, emphasizing the current need to develop strategies utilizing optimal biomaterials, modified surgical technique and pharmacologic therapy to minimize the systemic complications of CPB." @default.
- W2006647527 created "2016-06-24" @default.
- W2006647527 creator A5002905706 @default.
- W2006647527 date "2002-01-01" @default.
- W2006647527 modified "2023-10-17" @default.
- W2006647527 title "Cardiopulmonary bypass technology transfer: musings of a cardiac surgeon" @default.
- W2006647527 cites W118980958 @default.
- W2006647527 cites W136754475 @default.
- W2006647527 cites W1725919180 @default.
- W2006647527 cites W1971935437 @default.
- W2006647527 cites W1978346723 @default.
- W2006647527 cites W1982862444 @default.
- W2006647527 cites W1986577399 @default.
- W2006647527 cites W1987932602 @default.
- W2006647527 cites W1987981752 @default.
- W2006647527 cites W1992276483 @default.
- W2006647527 cites W1993253543 @default.
- W2006647527 cites W1994250597 @default.
- W2006647527 cites W1996820575 @default.
- W2006647527 cites W1999396642 @default.
- W2006647527 cites W2000421896 @default.
- W2006647527 cites W2002896686 @default.
- W2006647527 cites W2010836450 @default.
- W2006647527 cites W2015383094 @default.
- W2006647527 cites W2016261678 @default.
- W2006647527 cites W2019125924 @default.
- W2006647527 cites W2020571028 @default.
- W2006647527 cites W2022240776 @default.
- W2006647527 cites W2027350103 @default.
- W2006647527 cites W2028121321 @default.
- W2006647527 cites W2031464849 @default.
- W2006647527 cites W2035275795 @default.
- W2006647527 cites W2039656657 @default.
- W2006647527 cites W2040630794 @default.
- W2006647527 cites W2043136741 @default.
- W2006647527 cites W2043537777 @default.
- W2006647527 cites W2045498419 @default.
- W2006647527 cites W2048905315 @default.
- W2006647527 cites W2049099724 @default.
- W2006647527 cites W2053264658 @default.
- W2006647527 cites W2054674976 @default.
- W2006647527 cites W2056886225 @default.
- W2006647527 cites W2064790503 @default.
- W2006647527 cites W2065168681 @default.
- W2006647527 cites W2069507071 @default.
- W2006647527 cites W2077357590 @default.
- W2006647527 cites W2078021286 @default.
- W2006647527 cites W2078446943 @default.
- W2006647527 cites W2087653484 @default.
- W2006647527 cites W2088203721 @default.
- W2006647527 cites W2088259086 @default.
- W2006647527 cites W2089739019 @default.
- W2006647527 cites W2090792228 @default.
- W2006647527 cites W2092867359 @default.
- W2006647527 cites W2094550676 @default.
- W2006647527 cites W2095283049 @default.
- W2006647527 cites W2095868407 @default.
- W2006647527 cites W2103047609 @default.
- W2006647527 cites W2113871890 @default.
- W2006647527 cites W2115050042 @default.
- W2006647527 cites W2118192610 @default.
- W2006647527 cites W2129764349 @default.
- W2006647527 cites W2129820909 @default.
- W2006647527 cites W2131465617 @default.
- W2006647527 cites W2133467013 @default.
- W2006647527 cites W2136263973 @default.
- W2006647527 cites W2138849164 @default.
- W2006647527 cites W2142076308 @default.
- W2006647527 cites W2150244989 @default.
- W2006647527 cites W2152071347 @default.
- W2006647527 cites W2153545493 @default.
- W2006647527 cites W2164312004 @default.
- W2006647527 cites W2169621980 @default.
- W2006647527 cites W2172089138 @default.
- W2006647527 cites W2198426544 @default.
- W2006647527 cites W229396605 @default.
- W2006647527 cites W2397641428 @default.
- W2006647527 cites W2400483916 @default.
- W2006647527 cites W2403390399 @default.
- W2006647527 cites W2409330018 @default.
- W2006647527 cites W2409952955 @default.
- W2006647527 cites W2411854796 @default.
- W2006647527 cites W2418201508 @default.
- W2006647527 cites W2418426145 @default.
- W2006647527 cites W2419473844 @default.
- W2006647527 cites W2435303346 @default.
- W2006647527 cites W2442664055 @default.
- W2006647527 cites W2467965625 @default.
- W2006647527 cites W3111388598 @default.
- W2006647527 cites W4242722528 @default.
- W2006647527 cites W4245028793 @default.
- W2006647527 doi "https://doi.org/10.1163/156856202320253974" @default.
- W2006647527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12160305" @default.
- W2006647527 hasPublicationYear "2002" @default.
- W2006647527 type Work @default.
- W2006647527 sameAs 2006647527 @default.
- W2006647527 citedByCount "22" @default.
- W2006647527 countsByYear W20066475272012 @default.