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- W2006661510 abstract "In a group of 238 homosexual men a hepatitis B vaccine developed at the National Reference Center for Viral Hepatitis (Göttingen/Germany) was evaluated. The vaccine was well tolerated. Three intramuscular injections of inactivated HBsAg (subtype ad; 11300 Natl. Units/dose) induced antibody production in 89.7 % of the subjects. Four participants exhibited signs of hepatitis B infection. Vaccine recipients younger than 30 years produced higher antibody levels than older vaccinees. More than one half of the subjects who had only anti-HBs (anti-HBc negative) prior to immunization did not show an anamnestic booster response but formed IgM-anti-HBs. Antibody levels were significantly lower in anti-HBs negative/anti-HBc positive recipients than in subjects who had only anti-HBs or no hepatitis B markers. Immunological studies of T and B cell function did not provide conclusive evidence for the underlying cause of the different immune responses. In einer Gruppe von 238 homosexuellen Männern wurde die Wirksamkeit und Verträglichkeit der am Nationalen Referenzzentrum für die Virushepatitis (Göttingen) entwickelten Hepatitis-B-Vakzine geprüft. Der Impfstoff wurde gut vertragen. Dreimalige Impfung mit inaktiviertem HBsAg (Subtyp ad; 11300 Natl. Einh./Dosis) führte bei 89,7% aller Probanden zu einer Serokonversion. Bei 4 Impflingen ließen sich Zeichen einer Hepatitis B-Infektion unter der Impfung nachweisen. Probanden unter 30 Jahren bildeten höhere Antikörpertiter als ältere Impflinge. Mehr als die Hälfte der Probanden, bei denen sich vor der Impfung nur anti-HBs fand (anti-HBc negativ), bildeten IgM-anti-HBs wie nach einer Primärsensibilisierung. Anti-HBc positive/anti-HBs negative Probanden zeigten eine signifikant schwächere anti-HBs-Bildung als solche, die Anti-HBs positiv/anti-HBc negativ waren oder keine Hepatitis B-Marker aufwiesen. Untersuchungen von T- und B-Zellfunktionen ergaben keinen Aufschluß über die Ursache der unterschiedlichen Immunreaktionen." @default.
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- W2006661510 date "1985-11-01" @default.
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- W2006661510 title "Active Immunization Against Hepatitis B: Immunogenicity Study in Homosexual Men" @default.
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- W2006661510 doi "https://doi.org/10.1016/s0176-6724(85)80029-8" @default.
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