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• W2006670903 endingPage "1452" @default.
• W2006670903 startingPage "1437" @default.
• W2006670903 abstract "The bioavailability of drugs is often severely limited due to the presence of biological barriers in the form of epithelial tight junctions, efflux proteins and enzymatic degradation. Physicochemical properties, such as lipophilicity, molecular weight, charge, etc., also play key roles in determining the permeation properties of drug candidates. As a result, many potential drug candidates may be dropped from the initial screening portfolio. Prodrug derivatization targeting transporters and receptors expressed on mammalian cells holds tremendous potential. Enhanced cellular delivery can significantly improve drug absorption. Such approaches of drug targeting and delivery have been the subject of intense research. Various prodrugs have been designed that demonstrate enhanced bioavailability and tissue specificity. This approach is equally applicable to human and veterinary pharmaceuticals since most of the transporters and receptors expressed by human tissues are also expressed in animals. This review highlights studies conducted on the use of transporters and receptors in an effort to improve drug bioavailability and to develop targeted drug delivery systems." @default.
• W2006670903 created "2016-06-24" @default.
• W2006670903 creator A5040297353 @default.
• W2006670903 creator A5063175442 @default.
• W2006670903 creator A5078051329 @default.
• W2006670903 date "2004-06-01" @default.
• W2006670903 modified "2023-10-14" @default.
• W2006670903 title "Membrane transporter/receptor-targeted prodrug design: strategies for human and veterinary drug development" @default.
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