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- W2006675982 endingPage "53" @default.
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- W2006675982 abstract "Each of the thirteen identified Fanconi anemia (FA) genes is required for resistance to DNA interstrand crosslinking agents, such as mitomycin C, cisplatin, and melphalan. While these agents are excellent tools for understanding the function of FA proteins in DNA repair, it is uncertain whether a defect in the removal of DNA interstrand crosslinks (ICLs) is the basis for the pathophysiology of FA. For example, DNA interstrand crosslinking agents induce other types of DNA damage, in addition to ICLs. Further, other DNA-damaging agents, such as ionizing or ultraviolet radiation, activate the FA pathway, leading to monoubiquitination of FANCD2 and FANCI. Also, FA patients display congenital abnormalities, hematologic deficiencies, and a predisposition to cancer in the absence of an environmental source of ICLs that is external to cells. Here we consider potential sources of endogenous DNA damage, or endogenous stresses, to which FA proteins may respond. These include ICLs formed by products of lipid peroxidation, and other forms of oxidative DNA damage. FA proteins may also potentially respond to telomere shortening or replication stress. Defining these endogenous sources of DNA damage or stresses is critical for understanding the pathogenesis of deficiencies for FA proteins.We propose that FA proteins are centrally involved in the response to replication stress, including replication stress arising from oxidative DNA damage." @default.
- W2006675982 created "2016-06-24" @default.
- W2006675982 creator A5010286459 @default.
- W2006675982 creator A5083989242 @default.
- W2006675982 date "2009-07-01" @default.
- W2006675982 modified "2023-09-28" @default.
- W2006675982 title "Fanconi anemia proteins and endogenous stresses" @default.
- W2006675982 cites W1496836853 @default.
- W2006675982 cites W1507190685 @default.
- W2006675982 cites W1509230264 @default.
- W2006675982 cites W1516582678 @default.
- W2006675982 cites W1522788044 @default.
- W2006675982 cites W1562677361 @default.
- W2006675982 cites W1596008313 @default.
- W2006675982 cites W1724512254 @default.
- W2006675982 cites W1742238700 @default.
- W2006675982 cites W1950985345 @default.
- W2006675982 cites W1964609719 @default.
- W2006675982 cites W1965607924 @default.
- W2006675982 cites W1966398962 @default.
- W2006675982 cites W1966617758 @default.
- W2006675982 cites W1967630574 @default.
- W2006675982 cites W1969887535 @default.
- W2006675982 cites W1970891016 @default.
- W2006675982 cites W1971503458 @default.
- W2006675982 cites W1976895348 @default.
- W2006675982 cites W1977488724 @default.
- W2006675982 cites W1978631361 @default.
- W2006675982 cites W1979324654 @default.
- W2006675982 cites W1980676055 @default.
- W2006675982 cites W1981158444 @default.
- W2006675982 cites W1981457210 @default.
- W2006675982 cites W1982046131 @default.
- W2006675982 cites W1982609314 @default.
- W2006675982 cites W1983673827 @default.
- W2006675982 cites W1987316571 @default.
- W2006675982 cites W1989679224 @default.
- W2006675982 cites W1991591616 @default.
- W2006675982 cites W1991778691 @default.
- W2006675982 cites W1991841649 @default.
- W2006675982 cites W1992241785 @default.
- W2006675982 cites W1994053770 @default.
- W2006675982 cites W1994677283 @default.
- W2006675982 cites W1998048803 @default.
- W2006675982 cites W2000067413 @default.
- W2006675982 cites W2000206408 @default.
- W2006675982 cites W2000998571 @default.
- W2006675982 cites W2002150942 @default.
- W2006675982 cites W2003058744 @default.
- W2006675982 cites W2005284058 @default.
- W2006675982 cites W2010216792 @default.
- W2006675982 cites W2011319917 @default.
- W2006675982 cites W2012425247 @default.
- W2006675982 cites W2013805538 @default.
- W2006675982 cites W2016246684 @default.
- W2006675982 cites W2017821070 @default.
- W2006675982 cites W2018369441 @default.
- W2006675982 cites W2019219567 @default.
- W2006675982 cites W2020733732 @default.
- W2006675982 cites W2024667285 @default.
- W2006675982 cites W2024974524 @default.
- W2006675982 cites W2027931017 @default.
- W2006675982 cites W2028637581 @default.
- W2006675982 cites W2029164849 @default.
- W2006675982 cites W2029737881 @default.
- W2006675982 cites W2030705116 @default.
- W2006675982 cites W2034033535 @default.
- W2006675982 cites W2034580062 @default.
- W2006675982 cites W2034702779 @default.
- W2006675982 cites W2035003065 @default.
- W2006675982 cites W2036295786 @default.
- W2006675982 cites W2036639619 @default.
- W2006675982 cites W2038637560 @default.
- W2006675982 cites W2038692437 @default.
- W2006675982 cites W2040350157 @default.
- W2006675982 cites W2043411667 @default.
- W2006675982 cites W2043895957 @default.
- W2006675982 cites W2044503008 @default.
- W2006675982 cites W2045429308 @default.
- W2006675982 cites W2046884413 @default.
- W2006675982 cites W2048446461 @default.
- W2006675982 cites W2050608484 @default.
- W2006675982 cites W2052487588 @default.
- W2006675982 cites W2054605948 @default.
- W2006675982 cites W2054764151 @default.
- W2006675982 cites W2054886072 @default.
- W2006675982 cites W2058831361 @default.
- W2006675982 cites W2059508640 @default.
- W2006675982 cites W2060252723 @default.
- W2006675982 cites W2060792031 @default.
- W2006675982 cites W2064777323 @default.
- W2006675982 cites W2068062863 @default.
- W2006675982 cites W2068724764 @default.
- W2006675982 cites W2068764175 @default.
- W2006675982 cites W2069119604 @default.
- W2006675982 cites W2075700583 @default.
- W2006675982 cites W2075960489 @default.
- W2006675982 cites W2078242581 @default.