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- W2006682491 abstract "This mini-review summarizes current ideas of how hyperbaric gases (>1-10 atmospheres absolute) affect neuronal mechanisms of excitability through molecular interaction with membrane components. The dynamic nature of the lipid bilayer, its resident proteins, and the underlying cytoskeleton make each respective nanostructure a potential target for modulation by hyperbaric gases. Depending on the composition of the gas mixture, the relative concentrations of O(2) and inert gas, and total barometric pressure, the net effect of a particular gas on the cell membrane will be determined by the gas' 1) lipid solubility, 2) ability to oxidize lipids and proteins (O(2)), and 3) capacity, in the compressed state, to generate localized shear and strain forces between various nanostructures. A change in the properties of any one membrane component is anticipated to change conductance of membrane-spanning ion channels and thus neuronal function." @default.
- W2006682491 created "2016-06-24" @default.
- W2006682491 creator A5016645921 @default.
- W2006682491 creator A5043872671 @default.
- W2006682491 creator A5088053064 @default.
- W2006682491 date "2009-03-01" @default.
- W2006682491 modified "2023-10-09" @default.
- W2006682491 title "Effects of hyperbaric gases on membrane nanostructure and function in neurons" @default.
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- W2006682491 doi "https://doi.org/10.1152/japplphysiol.91070.2008" @default.
- W2006682491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18818382" @default.