FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006683721> ?p ?o ?g. }

• W2006683721 endingPage "813" @default.
• W2006683721 startingPage "805" @default.
• W2006683721 abstract "Ischemia and tumor necrosis factor-alpha (TNF alpha) released during ischemia both cause apoptosis and necrosis of myocardial tissues. Since endothelium may be critically important in determination of cardiac function, we examined the interaction between TNF alpha and hypoxia-reoxygenation with regard to induction of apoptosis and underlying signaling pathway in cultured human coronary artery endothelial cells (HCAECs).HCAECs were cultured and exposed to hypoxia alone, hypoxia-reoxygenation, TNF alpha alone, TNF alpha plus hypoxia-reoxygenation, or TNF alpha only during the period of reoxygenation. Apoptosis was evaluated by transmission electron microscopy, DNA nick-end labeling and DNA laddering. Hypoxia alone caused modest time-dependent apoptosis of cultured HCAECs, and reoxygenation increased the number of apoptotic cells (P < 0.01 vs. hypoxia alone). TNF alpha induced concentration-dependent apoptosis, and enhanced reoxygenation-mediated apoptosis in cultured HCAECs (P < 0.01 vs. hypoxia-reoxygenation alone). As expected, monoclonal antibody to TNF alpha significantly blocked the pro-apoptotic effect of TNF alpha-induced apoptosis (P < 0.01). TNF alpha-induced apoptosis was found to be associated with marked activation of protein kinase C (PKC), and pretreatment of cells with a specific PKC inhibitor markedly reduced TNF alpha-mediated PKC activity and apoptosis.These observations indicate that hypoxia alone causes modest apoptosis, reoxygenation increases apoptosis beyond that caused by hypoxia in cultured HCAECs. TNF alpha alone causes apoptosis, and further enhances apoptosis caused by hypoxia-reoxygenation. The activation of PKC plays a critical role in TNF alpha-induced apoptosis of cultured HCAECs." @default.
• W2006683721 created "2016-06-24" @default.
• W2006683721 creator A5009691150 @default.
• W2006683721 creator A5018438729 @default.
• W2006683721 creator A5035496984 @default.
• W2006683721 date "1999-06-01" @default.
• W2006683721 modified "2023-10-14" @default.
• W2006683721 title "Tumor necrosis factor-α enhances hypoxia–reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C" @default.
• W2006683721 cites W1633753176 @default.
• W2006683721 cites W178604975 @default.
• W2006683721 cites W1965937507 @default.
• W2006683721 cites W197144613 @default.
• W2006683721 cites W1976129366 @default.
• W2006683721 cites W1978504014 @default.
• W2006683721 cites W1984866351 @default.
• W2006683721 cites W1985812804 @default.
• W2006683721 cites W2006968633 @default.
• W2006683721 cites W2011477764 @default.
• W2006683721 cites W2013655880 @default.
• W2006683721 cites W2015639803 @default.
• W2006683721 cites W2058185635 @default.
• W2006683721 cites W2064717173 @default.
• W2006683721 cites W2068718379 @default.
• W2006683721 cites W2074299492 @default.
• W2006683721 cites W2078297328 @default.
• W2006683721 cites W2080453664 @default.
• W2006683721 cites W2081948388 @default.
• W2006683721 cites W2084224145 @default.
• W2006683721 cites W2084260830 @default.
• W2006683721 cites W2084470802 @default.
• W2006683721 cites W2091332539 @default.
• W2006683721 cites W2098946896 @default.
• W2006683721 cites W2104139750 @default.
• W2006683721 cites W2105054347 @default.
• W2006683721 cites W2115687718 @default.
• W2006683721 cites W2120751716 @default.
• W2006683721 cites W2126636055 @default.
• W2006683721 cites W2140598289 @default.
• W2006683721 cites W2148583002 @default.
• W2006683721 cites W2162282723 @default.
• W2006683721 cites W2166308479 @default.
• W2006683721 cites W2210549710 @default.
• W2006683721 cites W2408980564 @default.
• W2006683721 cites W28619635 @default.
• W2006683721 cites W28906986 @default.
• W2006683721 cites W2622133142 @default.
• W2006683721 doi "https://doi.org/10.1016/s0008-6363(98)00342-3" @default.
• W2006683721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10533621" @default.
• W2006683721 hasPublicationYear "1999" @default.
• W2006683721 type Work @default.
• W2006683721 sameAs 2006683721 @default.
• W2006683721 citedByCount "35" @default.
• W2006683721 countsByYear W20066837212012 @default.
• W2006683721 countsByYear W20066837212013 @default.
• W2006683721 countsByYear W20066837212014 @default.
• W2006683721 countsByYear W20066837212015 @default.
• W2006683721 countsByYear W20066837212017 @default.
• W2006683721 countsByYear W20066837212021 @default.
• W2006683721 crossrefType "journal-article" @default.
• W2006683721 hasAuthorship W2006683721A5009691150 @default.
• W2006683721 hasAuthorship W2006683721A5018438729 @default.
• W2006683721 hasAuthorship W2006683721A5035496984 @default.
• W2006683721 hasBestOaLocation W20066837211 @default.
• W2006683721 hasConcept C126322002 @default.
• W2006683721 hasConcept C134018914 @default.
• W2006683721 hasConcept C153911025 @default.
• W2006683721 hasConcept C155878803 @default.
• W2006683721 hasConcept C178790620 @default.
• W2006683721 hasConcept C17991360 @default.
• W2006683721 hasConcept C185592680 @default.
• W2006683721 hasConcept C190283241 @default.
• W2006683721 hasConcept C195794163 @default.
• W2006683721 hasConcept C31573885 @default.
• W2006683721 hasConcept C43759708 @default.
• W2006683721 hasConcept C503630168 @default.
• W2006683721 hasConcept C540031477 @default.
• W2006683721 hasConcept C55493867 @default.
• W2006683721 hasConcept C62478195 @default.
• W2006683721 hasConcept C71924100 @default.
• W2006683721 hasConcept C7836513 @default.
• W2006683721 hasConcept C86803240 @default.
• W2006683721 hasConcept C95444343 @default.
• W2006683721 hasConceptScore W2006683721C126322002 @default.
• W2006683721 hasConceptScore W2006683721C134018914 @default.
• W2006683721 hasConceptScore W2006683721C153911025 @default.
• W2006683721 hasConceptScore W2006683721C155878803 @default.
• W2006683721 hasConceptScore W2006683721C178790620 @default.
• W2006683721 hasConceptScore W2006683721C17991360 @default.
• W2006683721 hasConceptScore W2006683721C185592680 @default.
• W2006683721 hasConceptScore W2006683721C190283241 @default.
• W2006683721 hasConceptScore W2006683721C195794163 @default.
• W2006683721 hasConceptScore W2006683721C31573885 @default.
• W2006683721 hasConceptScore W2006683721C43759708 @default.
• W2006683721 hasConceptScore W2006683721C503630168 @default.
• W2006683721 hasConceptScore W2006683721C540031477 @default.
• W2006683721 hasConceptScore W2006683721C55493867 @default.
• W2006683721 hasConceptScore W2006683721C62478195 @default.
• W2006683721 hasConceptScore W2006683721C71924100 @default.

• next