FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006688676> ?p ?o ?g. }

• W2006688676 abstract "Nitrobenzene (NB) has been identified as a testicular toxicant in vivo, but its site of action remains unknown. In the present study, the effect of NB on the Sertoli cell was assessed in vitro using Sertoli cell and Sertoli-germ cell cocultures. The parameters measured were the exfoliation of germ cells; the secretion of lactate, pyruvate, and inhibin; and gross cellular morphology. The effect of metadinitrobenzene (mDNB), a related compound which is a known Sertoli cell toxicant, was assessed for comparison. Gross morphological changes including vacuolation of Sertoli cells were observed following treatment of cultures with 10(-3) M NB. Exposure of cocultures to NB also resulted in dose-dependent exfoliation of predominantly viable germ cells. NB (greater than 5 X 10(-4) M) and mDNB at the single dose level used (10(-4) M) stimulated the secretion of lactate and pyruvate significantly by Sertoli cells, an effect that was more marked in the absence of germ cells. Comparable changes were observed in follicle stimulating hormone (FSH)-stimulated cultures. Inhibin secretion by Sertoli cells was also altered by exposure to NB but in a biphasic manner, with low (10(-8) to 10(-6) M) and high (10(-4) to 10(-3) M) doses enhancing inhibin secretion while intermediate (10(-5) M) doses had no effect. These effects were evident in both culture systems but inhibin secretion by Sertoli-germ cell cocultures was always greater than that by Sertoli cell cultures. However, these effects of NB on inhibin secretion were not evident in FSH-stimulated cultures. In contrast to the effects of NB, mDNB had no effect on basal secretion of inhibin but blocked the stimulatory effect of FSH. It is concluded that NB, like mDNB, is probably a Sertoli cell toxicant in view of its similar disruptive effects on various parameters of Sertoli cell function. However, NB is far less toxic than mDNB at equivalent concentrations in vitro. The present study is the first to evaluate the potential of inhibin secretion by Sertoli cells in culture as an additional marker of toxicant action, and concludes that it merits further study in this context." @default.
• W2006688676 created "2016-06-24" @default.
• W2006688676 creator A5061594183 @default.
• W2006688676 date "1990-02-01" @default.
• W2006688676 modified "2023-09-25" @default.
• W2006688676 title "Changes in sertoli cell function in vitro induced by nitrobenzene" @default.
• W2006688676 cites W1822999471 @default.
• W2006688676 cites W1969664826 @default.
• W2006688676 cites W1976469412 @default.
• W2006688676 cites W1977977327 @default.
• W2006688676 cites W1983528787 @default.
• W2006688676 cites W2000311175 @default.
• W2006688676 cites W2000630807 @default.
• W2006688676 cites W2023455927 @default.
• W2006688676 cites W2041191405 @default.
• W2006688676 cites W2049015557 @default.
• W2006688676 cites W2051793438 @default.
• W2006688676 cites W2057161834 @default.
• W2006688676 cites W2063143513 @default.
• W2006688676 cites W2084616540 @default.
• W2006688676 cites W2125997040 @default.
• W2006688676 cites W2167193499 @default.
• W2006688676 cites W2895930656 @default.
• W2006688676 cites W587313402 @default.
• W2006688676 cites W2995475325 @default.
• W2006688676 doi "https://doi.org/10.1016/0272-0590(90)90216-7" @default.
• W2006688676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2108073" @default.
• W2006688676 hasPublicationYear "1990" @default.
• W2006688676 type Work @default.
• W2006688676 sameAs 2006688676 @default.
• W2006688676 citedByCount "23" @default.
• W2006688676 countsByYear W20066886762013 @default.
• W2006688676 countsByYear W20066886762016 @default.
• W2006688676 countsByYear W20066886762020 @default.
• W2006688676 crossrefType "journal-article" @default.
• W2006688676 hasAuthorship W2006688676A5061594183 @default.
• W2006688676 hasConcept C104317684 @default.
• W2006688676 hasConcept C123765429 @default.
• W2006688676 hasConcept C126322002 @default.
• W2006688676 hasConcept C134018914 @default.
• W2006688676 hasConcept C185592680 @default.
• W2006688676 hasConcept C2778575703 @default.
• W2006688676 hasConcept C2779122487 @default.
• W2006688676 hasConcept C2779279165 @default.
• W2006688676 hasConcept C2781068068 @default.
• W2006688676 hasConcept C49039625 @default.
• W2006688676 hasConcept C55493867 @default.
• W2006688676 hasConcept C71315377 @default.
• W2006688676 hasConcept C71924100 @default.
• W2006688676 hasConcept C86803240 @default.
• W2006688676 hasConcept C95444343 @default.
• W2006688676 hasConceptScore W2006688676C104317684 @default.
• W2006688676 hasConceptScore W2006688676C123765429 @default.
• W2006688676 hasConceptScore W2006688676C126322002 @default.
• W2006688676 hasConceptScore W2006688676C134018914 @default.
• W2006688676 hasConceptScore W2006688676C185592680 @default.
• W2006688676 hasConceptScore W2006688676C2778575703 @default.
• W2006688676 hasConceptScore W2006688676C2779122487 @default.
• W2006688676 hasConceptScore W2006688676C2779279165 @default.
• W2006688676 hasConceptScore W2006688676C2781068068 @default.
• W2006688676 hasConceptScore W2006688676C49039625 @default.
• W2006688676 hasConceptScore W2006688676C55493867 @default.
• W2006688676 hasConceptScore W2006688676C71315377 @default.
• W2006688676 hasConceptScore W2006688676C71924100 @default.
• W2006688676 hasConceptScore W2006688676C86803240 @default.
• W2006688676 hasConceptScore W2006688676C95444343 @default.
• W2006688676 hasLocation W20066886761 @default.
• W2006688676 hasLocation W20066886762 @default.
• W2006688676 hasOpenAccess W2006688676 @default.
• W2006688676 hasPrimaryLocation W20066886761 @default.
• W2006688676 hasRelatedWork W1967279915 @default.
• W2006688676 hasRelatedWork W1982783652 @default.
• W2006688676 hasRelatedWork W2014174007 @default.
• W2006688676 hasRelatedWork W2024553435 @default.
• W2006688676 hasRelatedWork W2049015557 @default.
• W2006688676 hasRelatedWork W2058133591 @default.
• W2006688676 hasRelatedWork W2063443812 @default.
• W2006688676 hasRelatedWork W2066575156 @default.
• W2006688676 hasRelatedWork W2078753179 @default.
• W2006688676 hasRelatedWork W4255681344 @default.
• W2006688676 isParatext "false" @default.
• W2006688676 isRetracted "false" @default.
• W2006688676 magId "2006688676" @default.
• W2006688676 workType "article" @default.