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- W2006691490 abstract "The action of meprobamate on conditioned behaviour was studied with cats. The subjects were trained to press a lever for food in a Skinner-☐ on a fixed-interval schedule of reinforcement. They develop a typical pattern of behaviour, characterized by a spontaneous temporal discrimination. Meprobamate increases the rate of responding and disrupts the temporal discrimination. These effects are similar to those obtained with chlordiazepoxide. Both effects are reduced and disappear with prolonged treatment (150 mg meprobamate daily). The tolerance extends to the general motor symptoms observed at the beggining of the treatment. When chlordiazepoxide is again administered after tolerance to meprobamate has developed, its effects on conditioned behaviour are still observed, though those on general motor behaviour are not (partial cross-tolerance). Animals treated with high doses show withdrawal reaction when the drug is no longer administered. L'action du méprobamate estétudiée sur le comportement conditionnédu chat. Dans une cage Skinner, les animaux sont entraînésàpresser sur une pédale pour obtenir de la nourriture, suivant un programme de renforcementàintervalle fixe. Ils développent spontanément un type de comportement caractérisépar de la discrimination temporelle. Le méprobamate détermine une augmentation du nombre de résponses et une détérioration de la discrimination temporelle. Ces effets sont similaires 3`a ceux engendrés par le chlordiazepoxide. Par traitement prolongé(150 mgpro die), ces deux types d'effets sont réduits ou disparaissent. La tolérance concerneégalement le syndrome moteur général observéau début du traitement. Le chlordiazepoxide, administréànouveau après développement de la tolérance au méprobamate, induit encore les meˆmes effets sur le comportement conditionnémais plus sur la motricitégénérale (tolérance croisée partielle). Avec des dosesélevées, le syndrome de sevrage apparaît lors de l'interruption de l'administration." @default.
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- W2006691490 title "Behavioural effects of a long-term treatment with meprobamate in cats" @default.
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- W2006691490 doi "https://doi.org/10.1016/0028-3908(65)90041-9" @default.
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