Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006700331> ?p ?o ?g. }
- W2006700331 endingPage "34" @default.
- W2006700331 startingPage "25" @default.
- W2006700331 abstract "Type VII collagen, the major component of anchoring fibrils, serves as tight adhesion of skin basement membrane zone (BMZ) through its amino-terminal non-collagenous (NC1) domain. The NC1 domain is targeted by autoantibodies of an acquired blistering skin disease termed epidermolysis bullosa acquisita (EBA) naturally occurring in humans and dogs. We cloned the full-length canine type VII collagen NC1 domain cDNA and delineated its molecular and immunological characteristics. The canine NC1 domain cDNA consists of 3759 nucleotides encoding for 1253 amino acids, with a molecular mass of approx. 134 kDa and a 17 amino acid signal peptide. The expression of canine type VII collagen was confirmed by Northern blot analysis and by a rabbit antibody raised against a 17 amino acid peptide deduced from canine NC1 sequence. Comparison of canine NC1 with the corresponding human sequence indicated 86.7% and 87.6% identity at the nucleotide and deduced amino acid levels respectively. The protein homology reached greater than 95% within two immunodominant epitope areas. Furthermore, human EBA autoantibodies and a rabbit anti-human NC1 cross-reacted with canine skin BMZ and the newly synthesized canine type VII collagen. The molecular and immunological identities between human and canine NC1 domains suggest that NC1 may be critical for the EBA development." @default.
- W2006700331 created "2016-06-24" @default.
- W2006700331 creator A5007855326 @default.
- W2006700331 creator A5013532908 @default.
- W2006700331 creator A5027358797 @default.
- W2006700331 creator A5030763743 @default.
- W2006700331 creator A5035052394 @default.
- W2006700331 creator A5088972500 @default.
- W2006700331 date "1998-10-01" @default.
- W2006700331 modified "2023-10-02" @default.
- W2006700331 title "Molecular cloning and characterization of a cDNA encoding canine type VII collagen non-collagenous (NC1) domain, the target antigen of autoimmune disease epidermolysis bullosa acquisita (EBA)" @default.
- W2006700331 cites W1512432174 @default.
- W2006700331 cites W1518102216 @default.
- W2006700331 cites W1520609171 @default.
- W2006700331 cites W1646327013 @default.
- W2006700331 cites W1980474802 @default.
- W2006700331 cites W1985380030 @default.
- W2006700331 cites W1986822633 @default.
- W2006700331 cites W1987568997 @default.
- W2006700331 cites W1998584863 @default.
- W2006700331 cites W2014473073 @default.
- W2006700331 cites W2026051888 @default.
- W2006700331 cites W2026129217 @default.
- W2006700331 cites W2032582642 @default.
- W2006700331 cites W2036730964 @default.
- W2006700331 cites W2038605297 @default.
- W2006700331 cites W2070870690 @default.
- W2006700331 cites W2073617532 @default.
- W2006700331 cites W2086077250 @default.
- W2006700331 cites W2092775031 @default.
- W2006700331 cites W2122309353 @default.
- W2006700331 cites W2124511738 @default.
- W2006700331 cites W2138270253 @default.
- W2006700331 cites W2142275262 @default.
- W2006700331 cites W2146059271 @default.
- W2006700331 cites W2150722878 @default.
- W2006700331 cites W2155771568 @default.
- W2006700331 cites W2168480622 @default.
- W2006700331 cites W2313977109 @default.
- W2006700331 cites W2399187687 @default.
- W2006700331 cites W4236243882 @default.
- W2006700331 cites W980313740 @default.
- W2006700331 doi "https://doi.org/10.1016/s0925-4439(98)00049-0" @default.
- W2006700331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9784596" @default.
- W2006700331 hasPublicationYear "1998" @default.
- W2006700331 type Work @default.
- W2006700331 sameAs 2006700331 @default.
- W2006700331 citedByCount "15" @default.
- W2006700331 countsByYear W20067003312012 @default.
- W2006700331 countsByYear W20067003312015 @default.
- W2006700331 countsByYear W20067003312022 @default.
- W2006700331 crossrefType "journal-article" @default.
- W2006700331 hasAuthorship W2006700331A5007855326 @default.
- W2006700331 hasAuthorship W2006700331A5013532908 @default.
- W2006700331 hasAuthorship W2006700331A5027358797 @default.
- W2006700331 hasAuthorship W2006700331A5030763743 @default.
- W2006700331 hasAuthorship W2006700331A5035052394 @default.
- W2006700331 hasAuthorship W2006700331A5088972500 @default.
- W2006700331 hasConcept C104317684 @default.
- W2006700331 hasConcept C105702510 @default.
- W2006700331 hasConcept C153911025 @default.
- W2006700331 hasConcept C159654299 @default.
- W2006700331 hasConcept C163764329 @default.
- W2006700331 hasConcept C167625842 @default.
- W2006700331 hasConcept C187882448 @default.
- W2006700331 hasConcept C189165786 @default.
- W2006700331 hasConcept C19218775 @default.
- W2006700331 hasConcept C195616568 @default.
- W2006700331 hasConcept C19924922 @default.
- W2006700331 hasConcept C203014093 @default.
- W2006700331 hasConcept C2776193487 @default.
- W2006700331 hasConcept C2777107211 @default.
- W2006700331 hasConcept C2779305546 @default.
- W2006700331 hasConcept C2779814568 @default.
- W2006700331 hasConcept C2781207856 @default.
- W2006700331 hasConcept C515207424 @default.
- W2006700331 hasConcept C54355233 @default.
- W2006700331 hasConcept C55493867 @default.
- W2006700331 hasConcept C86803240 @default.
- W2006700331 hasConceptScore W2006700331C104317684 @default.
- W2006700331 hasConceptScore W2006700331C105702510 @default.
- W2006700331 hasConceptScore W2006700331C153911025 @default.
- W2006700331 hasConceptScore W2006700331C159654299 @default.
- W2006700331 hasConceptScore W2006700331C163764329 @default.
- W2006700331 hasConceptScore W2006700331C167625842 @default.
- W2006700331 hasConceptScore W2006700331C187882448 @default.
- W2006700331 hasConceptScore W2006700331C189165786 @default.
- W2006700331 hasConceptScore W2006700331C19218775 @default.
- W2006700331 hasConceptScore W2006700331C195616568 @default.
- W2006700331 hasConceptScore W2006700331C19924922 @default.
- W2006700331 hasConceptScore W2006700331C203014093 @default.
- W2006700331 hasConceptScore W2006700331C2776193487 @default.
- W2006700331 hasConceptScore W2006700331C2777107211 @default.
- W2006700331 hasConceptScore W2006700331C2779305546 @default.
- W2006700331 hasConceptScore W2006700331C2779814568 @default.
- W2006700331 hasConceptScore W2006700331C2781207856 @default.
- W2006700331 hasConceptScore W2006700331C515207424 @default.
- W2006700331 hasConceptScore W2006700331C54355233 @default.