Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006702363> ?p ?o ?g. }
- W2006702363 endingPage "178" @default.
- W2006702363 startingPage "173" @default.
- W2006702363 abstract "Adipocyte accumulation is associated with the development of obesity and obesity-related diseases. Interactions of master transcription factors and signaling cascades are required for adipogenesis. Regulation of excessive adipogenic processes may be an attractive therapeutic for treatment of obesity and obesity-related diseases. In this study, we found that atorvastatin exerts an anti-adipogenic activity in 3T3-L1 pre-adipocytes, and that this activity is elevated in combination with metformin. Expression of the adipogenic master regulators PPARγ and C/EBPα, and their target gene aP2, was suppressed by atorvastatin. Furthermore, atorvastatin treatment resulted in increased activation of the key master regulator of cellular energy homeostasis, AMPK. These biological activities of atorvastatin were elevated in combination with metformin. These anti-adipogenic activities were associated with regulation of the STAT3 and TGF-β signaling cascades, resulting in the regulation of the expression of STAT3 target genes, such as KLF5, p53, and cyclin D1, and TGF-β signaling inhibitory genes, such as SMAD7. Our results suggest that combination therapy with atorvastatin and metformin may have therapeutic potential for the treatment of obesity and obesity-related diseases caused by excessive adipogenesis." @default.
- W2006702363 created "2016-06-24" @default.
- W2006702363 creator A5011254435 @default.
- W2006702363 creator A5018554746 @default.
- W2006702363 creator A5024889889 @default.
- W2006702363 creator A5062923713 @default.
- W2006702363 creator A5063916686 @default.
- W2006702363 creator A5071627434 @default.
- W2006702363 creator A5072606687 @default.
- W2006702363 creator A5086764274 @default.
- W2006702363 date "2015-01-01" @default.
- W2006702363 modified "2023-10-11" @default.
- W2006702363 title "Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling" @default.
- W2006702363 cites W136329886 @default.
- W2006702363 cites W1927710737 @default.
- W2006702363 cites W1976655891 @default.
- W2006702363 cites W1981155770 @default.
- W2006702363 cites W1989244177 @default.
- W2006702363 cites W1998744877 @default.
- W2006702363 cites W2000475291 @default.
- W2006702363 cites W2016701686 @default.
- W2006702363 cites W2021388182 @default.
- W2006702363 cites W2021431839 @default.
- W2006702363 cites W2024788721 @default.
- W2006702363 cites W2026231752 @default.
- W2006702363 cites W2036095317 @default.
- W2006702363 cites W2048147610 @default.
- W2006702363 cites W2051051060 @default.
- W2006702363 cites W2059431819 @default.
- W2006702363 cites W2059992589 @default.
- W2006702363 cites W2071188087 @default.
- W2006702363 cites W2079189474 @default.
- W2006702363 cites W2080295718 @default.
- W2006702363 cites W2086426509 @default.
- W2006702363 cites W2088652885 @default.
- W2006702363 cites W2091656563 @default.
- W2006702363 cites W2092398087 @default.
- W2006702363 cites W2095889878 @default.
- W2006702363 cites W2127194133 @default.
- W2006702363 cites W2154811382 @default.
- W2006702363 cites W2156865358 @default.
- W2006702363 cites W2157000986 @default.
- W2006702363 cites W2165405205 @default.
- W2006702363 cites W2170243742 @default.
- W2006702363 cites W2176176727 @default.
- W2006702363 cites W4245367233 @default.
- W2006702363 doi "https://doi.org/10.1016/j.bbrc.2014.11.054" @default.
- W2006702363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25462562" @default.
- W2006702363 hasPublicationYear "2015" @default.
- W2006702363 type Work @default.
- W2006702363 sameAs 2006702363 @default.
- W2006702363 citedByCount "20" @default.
- W2006702363 countsByYear W20067023632015 @default.
- W2006702363 countsByYear W20067023632016 @default.
- W2006702363 countsByYear W20067023632017 @default.
- W2006702363 countsByYear W20067023632021 @default.
- W2006702363 countsByYear W20067023632022 @default.
- W2006702363 countsByYear W20067023632023 @default.
- W2006702363 crossrefType "journal-article" @default.
- W2006702363 hasAuthorship W2006702363A5011254435 @default.
- W2006702363 hasAuthorship W2006702363A5018554746 @default.
- W2006702363 hasAuthorship W2006702363A5024889889 @default.
- W2006702363 hasAuthorship W2006702363A5062923713 @default.
- W2006702363 hasAuthorship W2006702363A5063916686 @default.
- W2006702363 hasAuthorship W2006702363A5071627434 @default.
- W2006702363 hasAuthorship W2006702363A5072606687 @default.
- W2006702363 hasAuthorship W2006702363A5086764274 @default.
- W2006702363 hasConcept C122927707 @default.
- W2006702363 hasConcept C126322002 @default.
- W2006702363 hasConcept C134018914 @default.
- W2006702363 hasConcept C171089720 @default.
- W2006702363 hasConcept C184235292 @default.
- W2006702363 hasConcept C185592680 @default.
- W2006702363 hasConcept C2776175234 @default.
- W2006702363 hasConcept C2777482532 @default.
- W2006702363 hasConcept C2778923194 @default.
- W2006702363 hasConcept C2780124434 @default.
- W2006702363 hasConcept C2780323712 @default.
- W2006702363 hasConcept C502942594 @default.
- W2006702363 hasConcept C555293320 @default.
- W2006702363 hasConcept C62478195 @default.
- W2006702363 hasConcept C71924100 @default.
- W2006702363 hasConcept C86803240 @default.
- W2006702363 hasConcept C95444343 @default.
- W2006702363 hasConcept C97029542 @default.
- W2006702363 hasConcept C98274493 @default.
- W2006702363 hasConceptScore W2006702363C122927707 @default.
- W2006702363 hasConceptScore W2006702363C126322002 @default.
- W2006702363 hasConceptScore W2006702363C134018914 @default.
- W2006702363 hasConceptScore W2006702363C171089720 @default.
- W2006702363 hasConceptScore W2006702363C184235292 @default.
- W2006702363 hasConceptScore W2006702363C185592680 @default.
- W2006702363 hasConceptScore W2006702363C2776175234 @default.
- W2006702363 hasConceptScore W2006702363C2777482532 @default.
- W2006702363 hasConceptScore W2006702363C2778923194 @default.
- W2006702363 hasConceptScore W2006702363C2780124434 @default.
- W2006702363 hasConceptScore W2006702363C2780323712 @default.
- W2006702363 hasConceptScore W2006702363C502942594 @default.