FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006702495> ?p ?o ?g. }

• W2006702495 endingPage "469" @default.
• W2006702495 startingPage "455" @default.
• W2006702495 abstract "Despite notable progress of the candidate-gene and genome-wide association studies (GWAS), understanding the role of genes contributing to human health and lifespan is still very limited. We use the Framingham Heart Study to elucidate if recognizing the role of evolution and systemic processes in an aging organism could advance such studies. We combine throughput methods of GWAS with more detail methods typical for candidate-gene analyses and show that both lifespan and ages at onset of CVD and cancer can be controlled by the same allelic variants. The risk allele carriers are at highly significant risk of premature death (e.g., RR=2.9, p=5.0 × 10(-66)), onset of CVD (e.g., RR=1.6, p=4.6 × 10(-17)), and onset of cancer (e.g., RR=1.6, p=1.5 × 10(-6)). The mechanism mediating the revealed genetic associations is likely associated with biological aging. These aging-related phenotypes are associated with a complex network which includes, in this study, 62 correlated SNPs even so these SNPs can be on non-homologous chromosomes. A striking result is three-fold, highly significant (p=3.6 × 10(-10)) enrichment of non-synonymous SNPs (N=27) in this network compared to the entire qualified set of the studied SNPs. Functional significance of this network is strengthened by involvement of genes for these SNPs in fundamental biological processes related to aging (e.g., response to stimuli, protein degradation, apoptosis) and by connections of these genes with neurological (20 genes) and cardio-vascular (nine genes) processes and tumorigenesis (10 genes). These results document challenging role of gene networks in regulating human health and aging and call for broadening focus on genomics of such phenotypes." @default.
• W2006702495 created "2016-06-24" @default.
• W2006702495 creator A5017898754 @default.
• W2006702495 creator A5041686825 @default.
• W2006702495 date "2011-12-16" @default.
• W2006702495 modified "2023-10-16" @default.
• W2006702495 title "Genomics of human health and aging" @default.
• W2006702495 cites W1484675493 @default.
• W2006702495 cites W1576955035 @default.
• W2006702495 cites W1586907427 @default.
• W2006702495 cites W1658682427 @default.
• W2006702495 cites W1884366156 @default.
• W2006702495 cites W1965684670 @default.
• W2006702495 cites W1966645907 @default.
• W2006702495 cites W1966794022 @default.
• W2006702495 cites W1969689301 @default.
• W2006702495 cites W1974967938 @default.
• W2006702495 cites W1977753891 @default.
• W2006702495 cites W1982261072 @default.
• W2006702495 cites W1984265860 @default.
• W2006702495 cites W1987493079 @default.
• W2006702495 cites W1988757966 @default.
• W2006702495 cites W1992444358 @default.
• W2006702495 cites W1992842030 @default.
• W2006702495 cites W1993066638 @default.
• W2006702495 cites W1993333521 @default.
• W2006702495 cites W2000632322 @default.
• W2006702495 cites W2001629081 @default.
• W2006702495 cites W2005649856 @default.
• W2006702495 cites W2012028008 @default.
• W2006702495 cites W2014282173 @default.
• W2006702495 cites W2027838121 @default.
• W2006702495 cites W2046247026 @default.
• W2006702495 cites W2048258507 @default.
• W2006702495 cites W2049107009 @default.
• W2006702495 cites W2057348944 @default.
• W2006702495 cites W2057583859 @default.
• W2006702495 cites W2058029138 @default.
• W2006702495 cites W2060458509 @default.
• W2006702495 cites W2063641249 @default.
• W2006702495 cites W2063836788 @default.
• W2006702495 cites W2072821115 @default.
• W2006702495 cites W2079078124 @default.
• W2006702495 cites W2081872599 @default.
• W2006702495 cites W2082137418 @default.
• W2006702495 cites W2082190201 @default.
• W2006702495 cites W2083045667 @default.
• W2006702495 cites W2084026374 @default.
• W2006702495 cites W2089610798 @default.
• W2006702495 cites W2092818456 @default.
• W2006702495 cites W2097349182 @default.
• W2006702495 cites W2098541838 @default.
• W2006702495 cites W2099610622 @default.
• W2006702495 cites W2100577029 @default.
• W2006702495 cites W2101983393 @default.
• W2006702495 cites W2104500246 @default.
• W2006702495 cites W2104738846 @default.
• W2006702495 cites W2105281057 @default.
• W2006702495 cites W2108470302 @default.
• W2006702495 cites W2113466108 @default.
• W2006702495 cites W2115801316 @default.
• W2006702495 cites W2117673537 @default.
• W2006702495 cites W2118729796 @default.
• W2006702495 cites W2122713183 @default.
• W2006702495 cites W2125576474 @default.
• W2006702495 cites W2129254992 @default.
• W2006702495 cites W2130532337 @default.
• W2006702495 cites W2136404471 @default.
• W2006702495 cites W2138755473 @default.
• W2006702495 cites W2139601198 @default.
• W2006702495 cites W2140026047 @default.
• W2006702495 cites W2140912789 @default.
• W2006702495 cites W2144779638 @default.
• W2006702495 cites W2148208805 @default.
• W2006702495 cites W2152317329 @default.
• W2006702495 cites W2154869964 @default.
• W2006702495 cites W2156104506 @default.
• W2006702495 cites W2161597310 @default.
• W2006702495 cites W2161633633 @default.
• W2006702495 cites W2161842981 @default.
• W2006702495 cites W2164672030 @default.
• W2006702495 cites W2166415858 @default.
• W2006702495 cites W2170089265 @default.
• W2006702495 cites W2170138349 @default.
• W2006702495 cites W2175258576 @default.
• W2006702495 cites W3022759478 @default.
• W2006702495 cites W4230655520 @default.
• W2006702495 cites W1970485971 @default.
• W2006702495 doi "https://doi.org/10.1007/s11357-011-9362-x" @default.
• W2006702495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3592948" @default.
• W2006702495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22174011" @default.
• W2006702495 hasPublicationYear "2011" @default.
• W2006702495 type Work @default.
• W2006702495 sameAs 2006702495 @default.
• W2006702495 citedByCount "15" @default.
• W2006702495 countsByYear W20067024952012 @default.
• W2006702495 countsByYear W20067024952013 @default.
• W2006702495 countsByYear W20067024952014 @default.

• next