FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006703052> ?p ?o ?g. }

• W2006703052 endingPage "1017" @default.
• W2006703052 startingPage "1014" @default.
• W2006703052 abstract "Despite the widespread use of the C21 progestin medroxyprogesterone acetate (MPA) in hormone replacement therapy and gynecological practice, its effects on bone density are uncertain, with contradictory reports in the literature. We have examined the short term changes in bone density at the lumbar spine (a predominantly trabecular site) and the femoral neck (a predominantly cortical site) in 13 premanopausal women prescribed high dose MPA (50 mg/day) for gynecological disorders and in 12 control subjects. Compared to basal values, lumbar spine bone mineral density (measured by dual energy x-ray absorptiometry) fell progressively by a mean 2.4% at 6 months and 4.1% at 12 months (both P < 0.01); in five subjects who continued the drug, it had fallen by a mean 5.9% at 20 months (P < 0.002). The spinal bone loss in the MPA users was significantly greater than that in controls (P < 0.005 at 6 months; P < 0.01 at 12 months) and occurred despite a significant gain in body weight in the women using MPA (median, 3.5 kg at 6 months; P < 0.01). In four subjects in whom bone density was measured 6 months after cessation of MPA, spinal bone density showed significant recovery (mean increment, 2.8%; P < 0.025). Femoral neck bone density measurements did not differ between the groups. MPA induced amenorrhea in all subjects who continued with it beyond 6 months, and the amenorrheic subjects were estrogen deficient (median plasma estradiol, 70 pmol/L). We conclude that, when given in doses sufficient to induce hypogonadism, MPA use is associated with significant early loss of trabecular bone, which is probably the consequence of estrogen deficiency." @default.
• W2006703052 created "2016-06-24" @default.
• W2006703052 creator A5012954568 @default.
• W2006703052 creator A5029418892 @default.
• W2006703052 creator A5057360890 @default.
• W2006703052 creator A5058399747 @default.
• W2006703052 date "1996-03-01" @default.
• W2006703052 modified "2023-09-27" @default.
• W2006703052 title "Short-term effects of high dose oral medroxyprogesterone acetate on bone density in premenopausal women." @default.
• W2006703052 cites W177707415 @default.
• W2006703052 cites W1976393638 @default.
• W2006703052 cites W1979061244 @default.
• W2006703052 cites W1983148243 @default.
• W2006703052 cites W1996025707 @default.
• W2006703052 cites W2000036618 @default.
• W2006703052 cites W2002535656 @default.
• W2006703052 cites W2004236425 @default.
• W2006703052 cites W2004788488 @default.
• W2006703052 cites W2056432929 @default.
• W2006703052 cites W2060679954 @default.
• W2006703052 cites W2061958057 @default.
• W2006703052 cites W2072195133 @default.
• W2006703052 cites W2073911284 @default.
• W2006703052 cites W2084540405 @default.
• W2006703052 cites W2089856942 @default.
• W2006703052 cites W2096404822 @default.
• W2006703052 cites W2100072820 @default.
• W2006703052 cites W2323266720 @default.
• W2006703052 doi "https://doi.org/10.1210/jcem.81.3.8772567" @default.
• W2006703052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8772567" @default.
• W2006703052 hasPublicationYear "1996" @default.
• W2006703052 type Work @default.
• W2006703052 sameAs 2006703052 @default.
• W2006703052 citedByCount "19" @default.
• W2006703052 countsByYear W20067030522012 @default.
• W2006703052 countsByYear W20067030522014 @default.
• W2006703052 countsByYear W20067030522015 @default.
• W2006703052 countsByYear W20067030522017 @default.
• W2006703052 countsByYear W20067030522018 @default.
• W2006703052 crossrefType "journal-article" @default.
• W2006703052 hasAuthorship W2006703052A5012954568 @default.
• W2006703052 hasAuthorship W2006703052A5029418892 @default.
• W2006703052 hasAuthorship W2006703052A5057360890 @default.
• W2006703052 hasAuthorship W2006703052A5058399747 @default.
• W2006703052 hasBestOaLocation W20067030521 @default.
• W2006703052 hasConcept C126322002 @default.
• W2006703052 hasConcept C126894567 @default.
• W2006703052 hasConcept C134018914 @default.
• W2006703052 hasConcept C136496925 @default.
• W2006703052 hasConcept C2775854910 @default.
• W2006703052 hasConcept C2775934596 @default.
• W2006703052 hasConcept C2776169692 @default.
• W2006703052 hasConcept C2776306185 @default.
• W2006703052 hasConcept C2776541429 @default.
• W2006703052 hasConcept C2776607906 @default.
• W2006703052 hasConcept C2776886416 @default.
• W2006703052 hasConcept C2777164284 @default.
• W2006703052 hasConcept C2778058571 @default.
• W2006703052 hasConcept C2779234561 @default.
• W2006703052 hasConcept C2779329777 @default.
• W2006703052 hasConcept C54355233 @default.
• W2006703052 hasConcept C71924100 @default.
• W2006703052 hasConcept C86803240 @default.
• W2006703052 hasConceptScore W2006703052C126322002 @default.
• W2006703052 hasConceptScore W2006703052C126894567 @default.
• W2006703052 hasConceptScore W2006703052C134018914 @default.
• W2006703052 hasConceptScore W2006703052C136496925 @default.
• W2006703052 hasConceptScore W2006703052C2775854910 @default.
• W2006703052 hasConceptScore W2006703052C2775934596 @default.
• W2006703052 hasConceptScore W2006703052C2776169692 @default.
• W2006703052 hasConceptScore W2006703052C2776306185 @default.
• W2006703052 hasConceptScore W2006703052C2776541429 @default.
• W2006703052 hasConceptScore W2006703052C2776607906 @default.
• W2006703052 hasConceptScore W2006703052C2776886416 @default.
• W2006703052 hasConceptScore W2006703052C2777164284 @default.
• W2006703052 hasConceptScore W2006703052C2778058571 @default.
• W2006703052 hasConceptScore W2006703052C2779234561 @default.
• W2006703052 hasConceptScore W2006703052C2779329777 @default.
• W2006703052 hasConceptScore W2006703052C54355233 @default.
• W2006703052 hasConceptScore W2006703052C71924100 @default.
• W2006703052 hasConceptScore W2006703052C86803240 @default.
• W2006703052 hasIssue "3" @default.
• W2006703052 hasLocation W20067030521 @default.
• W2006703052 hasLocation W20067030522 @default.
• W2006703052 hasOpenAccess W2006703052 @default.
• W2006703052 hasPrimaryLocation W20067030521 @default.
• W2006703052 hasRelatedWork W1532203024 @default.
• W2006703052 hasRelatedWork W1974936404 @default.
• W2006703052 hasRelatedWork W2006703052 @default.
• W2006703052 hasRelatedWork W2028590998 @default.
• W2006703052 hasRelatedWork W2065832801 @default.
• W2006703052 hasRelatedWork W2072756474 @default.
• W2006703052 hasRelatedWork W2078390130 @default.
• W2006703052 hasRelatedWork W2083030277 @default.
• W2006703052 hasRelatedWork W2087709775 @default.
• W2006703052 hasRelatedWork W2322234873 @default.
• W2006703052 hasVolume "81" @default.
• W2006703052 isParatext "false" @default.

• next