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• W2006703490 abstract "For decades, cancer research has focussed on the genetic defects that drive tumourigenesis. However, recent high-resolution sequencing studies have uncovered mounting evidence for the complementary role of epigenetic deregulation as a hallmark of haematological malignancies. The reversibility of epigenetic changes makes them suitable candidates for pharmacological manipulation and therapeutic targeting.This review summarises the mechanisms of normal epigenetic regulation and how these are perturbed in haematological malignancies as a result of genetic alterations. The article concludes with how these can be reversed and appraises the investigational epigenetically targeted therapies in preclinical and clinical use.The identification of recurring alterations in components of the epigenome of leukaemia and lymphoma has driven the rapid development of highly potent epigenetically targeted therapies. This rapid development has alluded to the possibility of a personalised therapeutic approach in selected patient populations. An enhanced understanding of the biological effects of these epigenetic alterations in initiation and progression of haematological malignancies, together with a clear mechanistic insight into how the drugs reverse the phenotypes, will define their translation into routine clinical use." @default.
• W2006703490 created "2016-06-24" @default.
• W2006703490 creator A5045582236 @default.
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• W2006703490 date "2014-05-26" @default.
• W2006703490 modified "2023-09-23" @default.
• W2006703490 title "Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies" @default.
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• W2006703490 doi "https://doi.org/10.1517/13543784.2014.923402" @default.
• W2006703490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24855903" @default.
• W2006703490 hasPublicationYear "2014" @default.
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