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- W2006706717 abstract "A HPLC assay method was modified and validated for the determination of 5-fluorouracil in human red blood cells, plasma and whole blood with a two-fold increased sensitivity (detection limit=10 ng/ml). The assay was linear from 25 to 1500 ng/ml and the accuracy ranged from 96.7 to 103.2% at 25 ng/ml, 94.8 to 99.4% at 500 ng/ml, and 98.9 to 99.5% at 1500 ng/ml. Intra-assay and inter-assay coefficients of variation were less than 8% over the range of concentrations and less than 8% over 10 days of analysis. After intravenous bolus and infusion of 5-fluorouracil in patients with colorectal cancer, the concentrations of 5-fluorouracil in whole blood were 108-111% of plasma concentrations, while packed red blood cells levels were 8-15% of plasma concentrations in the five patients studied. By utilising basic analytical hardware, this represents an accurate, precise, reproducible and affordable method for 5-fluorouracil pharmacokinetics investigation and therapeutic drug monitoring." @default.
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- W2006706717 date "1997-04-01" @default.
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- W2006706717 title "High-performance liquid chromatographic assay of 5-fluorouracil in human erythrocytes, plasma and whole blood" @default.
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- W2006706717 doi "https://doi.org/10.1016/s0378-4347(96)00485-9" @default.
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