FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W200671251> ?p ?o ?g. }

• W200671251 abstract "Abstract Introduction Memory B cells (MBCs) remain viable in a non-proliferative state for years. These cells express genes involved in cell survival and anti-apoptotic factors, while repress the expression of cell cycle regulatory genes. During their differentiation into plasma cells (PCs), these cells develop an opposite gene expression pattern, with a higher expression of genes implicated in cell proliferation and activation, and a lower expression of survival genes. In multiple myeloma (MM) the PCs accumulate into the bone marrow due, at least in part, to failure of pro-apoptotic mechanisms normally expressed in PCs. In the present study we analyzed the gene expression patterns of MBCs and PCs from healthy donors and patients with MM, in order to determine whether or not myelomatous PCs share characteristics of MBCs and/or normal PCs, and to identify possible genes related to the pathophysiology of the disease. Methods MBCs were obtained by immunomagnetic separation from buffy coats of 5 aged healthy donors. Likewise, PCs were isolated from bone marrow of 6 healthy donors and of 5 patients with MM. Using microarray techniques we analyzed the expression of 45000 genes in all samples. We performed unsupervised hierarchical cluster of gene expression data using the average linkage and the Euclidean distance. To identify differentially expressed genes among experimental groups we applied non-parametric Kruskal Wallis test. The differences in expression with a p value < 0.05 were considered significant. All analyses were performed using the Multi-experiment Viewer 4.7.1 software. Results From the hierarchical cluster obtained we clearly identified two groups, one which included normal PCs samples and the other one containing myelomatous PCs and MBCs. Interestingly, myelomatous PCs displayed intermediate features between MBCs and normal PCs (Figure 1). We found 5159 genes differentially expressed between normal and myelomatous PCs. Among these, we identified 3455 genes which displayed a similar expression pattern between MBCs and myelomatous PCs, including caspases inhibitors, MAP kinases, ubiquitins, transcription and translation factors. Conclusion Myelomatous PCs display an intermediate gene expression pattern between normal PCs and MBCs. These cells display high expression of genes involved in cell survival that should be normally inactivated in the transit of MBC to a normal PC, so that its expression pattern is closer to a MBC than a normal PC. Disclosures: No relevant conflicts of interest to declare." @default.
• W200671251 created "2016-06-24" @default.
• W200671251 creator A5000167599 @default.
• W200671251 creator A5006232219 @default.
• W200671251 creator A5008339619 @default.
• W200671251 creator A5036571657 @default.
• W200671251 creator A5059593651 @default.
• W200671251 creator A5066183078 @default.
• W200671251 creator A5080650923 @default.
• W200671251 creator A5086683153 @default.
• W200671251 creator A5089418637 @default.
• W200671251 creator A5089841174 @default.
• W200671251 creator A5090939618 @default.
• W200671251 date "2013-11-15" @default.
• W200671251 modified "2023-10-18" @default.
• W200671251 title "Myelomatous Plasma Cells Display An Intermediate Gene Expression Pattern Between a Normal Plasma Cell and a Memory B Cell" @default.
• W200671251 doi "https://doi.org/10.1182/blood.v122.21.1892.1892" @default.
• W200671251 hasPublicationYear "2013" @default.
• W200671251 type Work @default.
• W200671251 sameAs 200671251 @default.
• W200671251 citedByCount "0" @default.
• W200671251 crossrefType "journal-article" @default.
• W200671251 hasAuthorship W200671251A5000167599 @default.
• W200671251 hasAuthorship W200671251A5006232219 @default.
• W200671251 hasAuthorship W200671251A5008339619 @default.
• W200671251 hasAuthorship W200671251A5036571657 @default.
• W200671251 hasAuthorship W200671251A5059593651 @default.
• W200671251 hasAuthorship W200671251A5066183078 @default.
• W200671251 hasAuthorship W200671251A5080650923 @default.
• W200671251 hasAuthorship W200671251A5086683153 @default.
• W200671251 hasAuthorship W200671251A5089418637 @default.
• W200671251 hasAuthorship W200671251A5089841174 @default.
• W200671251 hasAuthorship W200671251A5090939618 @default.
• W200671251 hasConcept C104317684 @default.
• W200671251 hasConcept C150194340 @default.
• W200671251 hasConcept C153911025 @default.
• W200671251 hasConcept C18431079 @default.
• W200671251 hasConcept C203014093 @default.
• W200671251 hasConcept C2776364478 @default.
• W200671251 hasConcept C2776396001 @default.
• W200671251 hasConcept C2778285947 @default.
• W200671251 hasConcept C2780007613 @default.
• W200671251 hasConcept C54355233 @default.
• W200671251 hasConcept C62112901 @default.
• W200671251 hasConcept C86803240 @default.
• W200671251 hasConceptScore W200671251C104317684 @default.
• W200671251 hasConceptScore W200671251C150194340 @default.
• W200671251 hasConceptScore W200671251C153911025 @default.
• W200671251 hasConceptScore W200671251C18431079 @default.
• W200671251 hasConceptScore W200671251C203014093 @default.
• W200671251 hasConceptScore W200671251C2776364478 @default.
• W200671251 hasConceptScore W200671251C2776396001 @default.
• W200671251 hasConceptScore W200671251C2778285947 @default.
• W200671251 hasConceptScore W200671251C2780007613 @default.
• W200671251 hasConceptScore W200671251C54355233 @default.
• W200671251 hasConceptScore W200671251C62112901 @default.
• W200671251 hasConceptScore W200671251C86803240 @default.
• W200671251 hasLocation W2006712511 @default.
• W200671251 hasOpenAccess W200671251 @default.
• W200671251 hasPrimaryLocation W2006712511 @default.
• W200671251 hasRelatedWork W1979443864 @default.
• W200671251 hasRelatedWork W2001692150 @default.
• W200671251 hasRelatedWork W2030985028 @default.
• W200671251 hasRelatedWork W2060298161 @default.
• W200671251 hasRelatedWork W2071918798 @default.
• W200671251 hasRelatedWork W2091096579 @default.
• W200671251 hasRelatedWork W2093542167 @default.
• W200671251 hasRelatedWork W2118672196 @default.
• W200671251 hasRelatedWork W2135116572 @default.
• W200671251 hasRelatedWork W2144162609 @default.
• W200671251 hasRelatedWork W2372247695 @default.
• W200671251 hasRelatedWork W2485062141 @default.
• W200671251 hasRelatedWork W2530344585 @default.
• W200671251 hasRelatedWork W2565088959 @default.
• W200671251 hasRelatedWork W2594486763 @default.
• W200671251 hasRelatedWork W2944177326 @default.
• W200671251 hasRelatedWork W3030237479 @default.
• W200671251 hasRelatedWork W3115120057 @default.
• W200671251 hasRelatedWork W3200165127 @default.
• W200671251 hasRelatedWork W3208996322 @default.
• W200671251 isParatext "false" @default.
• W200671251 isRetracted "false" @default.
• W200671251 magId "200671251" @default.
• W200671251 workType "article" @default.