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- W2006717114 abstract "We report a case of recurrent vulvar ulcerations developed on vegetations associated with Crohn's disease. Lesions responded to low-dose thalidomide treatment. A biopsy revealed a neutrophilic infiltrate with rare giant cells. Vulvar manifestations were consistent with metastatic Crohn's disease or with a reactive neutrophilic dermatitis. Thalidomide reduces the activity of tumor necrosis factor (TNF) alpha by accelerating the degradation of its mRNA. Nowadays, it has become a promising drug in a broad variety of disorders in which TNF-alpha seems to play a pivotal role, including inflammatory bowel diseases. This is the first case report presenting the efficacy of thalidomide in the treatment of vulvar involvement in Crohn's disease." @default.
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- W2006717114 date "2003-01-01" @default.
- W2006717114 modified "2023-10-16" @default.
- W2006717114 title "Thalidomide in Refractory Vulvar Ulcerations Associated with Crohn’s Disease" @default.
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- W2006717114 doi "https://doi.org/10.1159/000069963" @default.
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