Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006720018> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2006720018 endingPage "814" @default.
- W2006720018 startingPage "811" @default.
- W2006720018 abstract "Analysis of EGFr and ER was performed on tumour samples from 231 patients with operable breast cancer followed for up to 6 yr after surgery. The median duration of follow-up in patients still alive at the time of analysis was 45 months. Thirty-five percent of patients (82) had tumours greater than 10 fmol/mg 125I-EGF binding (EGFr+) and 47% (109) had cystolic ER concentration greater than 5 fmol/mg (ER+), with a marked inverse relationship between EGFr and ER (P less than 0.00001). EGFr was second only to axillary node status as a prognostic marker for all patients both in terms of relapse-free and overall survival (P less than 0.001, logrank EGFr+ vs EGFr-). For patients with histologically negative axillary nodes EGFr was superior to ER in predicting relapse and survival (P less than 0.01 and P less than 0.005, respectively, compared to P less than 0.1 and P less than 0.1, logrank). In a multivariate (Cox model) analysis only EGFr, out of EGFr, ER, size and grade, was predictive for either relapse-free or overall survival for patients with node-negative disease (P = 0.052 and P = 0.026, respectively). The correlation of neu expression with response to tamoxifen in patients with recurrent disease was assessed immunochemically. Response rate was reduced in the presence of neu from 50 to 17% for ER+ cases and from 26 to 0% for ER- cases." @default.
- W2006720018 created "2016-06-24" @default.
- W2006720018 creator A5003685480 @default.
- W2006720018 creator A5008343934 @default.
- W2006720018 creator A5015402059 @default.
- W2006720018 creator A5042356736 @default.
- W2006720018 creator A5066067660 @default.
- W2006720018 creator A5068362864 @default.
- W2006720018 creator A5079633934 @default.
- W2006720018 creator A5080410026 @default.
- W2006720018 date "1990-12-01" @default.
- W2006720018 modified "2023-10-15" @default.
- W2006720018 title "Epidermal growth factor receptor (EGFr) as a marker for poor prognosis in node-negative breast cancer patients: Neu and tamoxifen failure" @default.
- W2006720018 cites W1924240366 @default.
- W2006720018 cites W1972637700 @default.
- W2006720018 cites W1975018566 @default.
- W2006720018 cites W1990968618 @default.
- W2006720018 cites W2013472456 @default.
- W2006720018 cites W2026578950 @default.
- W2006720018 cites W2032575695 @default.
- W2006720018 cites W2038252730 @default.
- W2006720018 cites W2076667824 @default.
- W2006720018 cites W2077689919 @default.
- W2006720018 cites W2153837633 @default.
- W2006720018 doi "https://doi.org/10.1016/0960-0760(90)90424-j" @default.
- W2006720018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2285594" @default.
- W2006720018 hasPublicationYear "1990" @default.
- W2006720018 type Work @default.
- W2006720018 sameAs 2006720018 @default.
- W2006720018 citedByCount "142" @default.
- W2006720018 countsByYear W20067200182012 @default.
- W2006720018 countsByYear W20067200182013 @default.
- W2006720018 countsByYear W20067200182014 @default.
- W2006720018 countsByYear W20067200182015 @default.
- W2006720018 countsByYear W20067200182017 @default.
- W2006720018 countsByYear W20067200182019 @default.
- W2006720018 countsByYear W20067200182021 @default.
- W2006720018 crossrefType "journal-article" @default.
- W2006720018 hasAuthorship W2006720018A5003685480 @default.
- W2006720018 hasAuthorship W2006720018A5008343934 @default.
- W2006720018 hasAuthorship W2006720018A5015402059 @default.
- W2006720018 hasAuthorship W2006720018A5042356736 @default.
- W2006720018 hasAuthorship W2006720018A5066067660 @default.
- W2006720018 hasAuthorship W2006720018A5068362864 @default.
- W2006720018 hasAuthorship W2006720018A5079633934 @default.
- W2006720018 hasAuthorship W2006720018A5080410026 @default.
- W2006720018 hasConcept C121608353 @default.
- W2006720018 hasConcept C126322002 @default.
- W2006720018 hasConcept C143998085 @default.
- W2006720018 hasConcept C2777176818 @default.
- W2006720018 hasConcept C2779438470 @default.
- W2006720018 hasConcept C38180746 @default.
- W2006720018 hasConcept C50382708 @default.
- W2006720018 hasConcept C530470458 @default.
- W2006720018 hasConcept C71924100 @default.
- W2006720018 hasConceptScore W2006720018C121608353 @default.
- W2006720018 hasConceptScore W2006720018C126322002 @default.
- W2006720018 hasConceptScore W2006720018C143998085 @default.
- W2006720018 hasConceptScore W2006720018C2777176818 @default.
- W2006720018 hasConceptScore W2006720018C2779438470 @default.
- W2006720018 hasConceptScore W2006720018C38180746 @default.
- W2006720018 hasConceptScore W2006720018C50382708 @default.
- W2006720018 hasConceptScore W2006720018C530470458 @default.
- W2006720018 hasConceptScore W2006720018C71924100 @default.
- W2006720018 hasIssue "6" @default.
- W2006720018 hasLocation W20067200181 @default.
- W2006720018 hasLocation W20067200182 @default.
- W2006720018 hasOpenAccess W2006720018 @default.
- W2006720018 hasPrimaryLocation W20067200181 @default.
- W2006720018 hasRelatedWork W1968489944 @default.
- W2006720018 hasRelatedWork W2020016788 @default.
- W2006720018 hasRelatedWork W2062795632 @default.
- W2006720018 hasRelatedWork W2111940104 @default.
- W2006720018 hasRelatedWork W2112427223 @default.
- W2006720018 hasRelatedWork W2151206172 @default.
- W2006720018 hasRelatedWork W2327258659 @default.
- W2006720018 hasRelatedWork W4248962432 @default.
- W2006720018 hasRelatedWork W4366694878 @default.
- W2006720018 hasRelatedWork W2183291585 @default.
- W2006720018 hasVolume "37" @default.
- W2006720018 isParatext "false" @default.
- W2006720018 isRetracted "false" @default.
- W2006720018 magId "2006720018" @default.
- W2006720018 workType "article" @default.