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- W2006722291 abstract "• Introduction • Classification of miRNA-related SNPs - SNPs in miRNA processing machinery - SNPs in pri-, pre-, mat-miRNAs - SNPs in miRNA-binding sites • MiRNA-related SNPs and solid cancer - Breast cancer - Colorectal cancer - Lung cancer - Prostate cancer - Renal cell carcinoma - Cervical cancer - Ovarian cancer - Gastric cancer - Bladder cancer - Oesophageal cancer - Hepatocellular carcinoma - Head and neck cancer - Thyroid cancer - Glioma • Conclusions and future directions MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, primary miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3′ untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers." @default.
- W2006722291 created "2016-06-24" @default.
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- W2006722291 creator A5066367567 @default.
- W2006722291 creator A5068398716 @default.
- W2006722291 creator A5090844895 @default.
- W2006722291 date "2011-12-29" @default.
- W2006722291 modified "2023-10-17" @default.
- W2006722291 title "Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer" @default.
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- W2006722291 doi "https://doi.org/10.1111/j.1582-4934.2011.01359.x" @default.
- W2006722291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3823089" @default.
- W2006722291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21692980" @default.
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