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- W2006753307 abstract "Recent evidence suggests that the effect of the addition or omission of a drug to or from a treatment protocol for ALL depends on the context of the whole program (1). A pilot study was undertaken to test the effect of L-asparaginase on remission duration in children with ALL under treatment protocol “Freiburg 71”. which is similar to Memphis protocol “Total VII”(2). 30 children with ALL were randomized to receive either vincristine+prednisone or vlncristine+prednisone+L-asp (1000E per kg once weekly x5, each dose being applied 24 h after VCR) Induction in both groups was followed by cranial irradiation (2400 rad) and i.th. MTX. Remission was maintained by oral 6-MP (50 mg/m2/d) + alternating 8-week courses of MTX (75-150 mg/m2/2wk. i.v. x4) and cyclophospnamide 600 mg/m2/2wk. i.v. x4). 13/15 children achieved remission in each group. Considerable toxicity of L-asp was observed from the third L-asp infusion on. After an observation time of 24-56 (median 42) months 8/13 children are in continuous remission in the VCR+pred+L-asp-group compared to 5/13 children in the VCR+pred-group. L-asp improves the results of this treatment protocol. Ref.: 1)Simone, J.V.: Brit. J. Haematol. 32, 465 (1976) 2)Wehinger, H. et al.: Strahlentherapie 148, 590 (1974)" @default.
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- W2006753307 date "1978-01-01" @default.
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- W2006753307 title "L-ASPARAGINASE AS A THIRD DRUG FOR REMISSION INDUCTION IN ALL. EFFECT ON REMISSION DURATION IN A RANDOMIZED PILOT STUDY" @default.
- W2006753307 doi "https://doi.org/10.1203/00006450-197801000-00079" @default.
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