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• W2006760925 abstract "Background Recent clinical studies have demonstrated the efficacy of erythromycin for treating patients with chronic lower respiratory tract inflammation. Mechanisms related to the anti-inflammatory action are yet to be determined. Objectives The therapeutic efficacy of erythromycin in experimental extrinsic allergic alveolitis (EAA) was evaluated. Methods A murine model of EAA was developed by intratracheal inoculations with particulate Trichosporon mucoides followed by erythromycin or josamycin treatment. Cell populations, specific antibodies, chemotactic activities, TNF-α, IL-1β, MIP-2 and KC of bronchoalveolar lavage fluid (BALF); histopathology of the lung and footpad reaction; myeloperoxidase of the whole lung; and immunohistochemistry of intercellular adhesion molecule-1 (ICAM-1), at 6 and 96 h after the challenge, were examined. Results There was a marked neutrophilic alveolitis and bronchiolitis at 6 h, and lymphocytic alveolitis and perivenule cuffing at 96 h after the challenge. Increase in total inflammatory cells and neutrophils in BALF at 6 h was significantly suppressed by pre-treatment with 5 mg/kg/day of erythromycin intraperitoneally for 5 days (P < 0.01), with no apparent effect on specific antibodies, chemotactic activity or cytokines. Erythromycin also suppressed the Arthus-type reaction in the footpad (P < 0.01). Histopathological studies revealed that erythromycin markedly decreased neutrophils in the lung and skin lesions and myeloperoxidase in the lung, simultaneously with inhibiting ICAM-1 expression. The therapy has no remarkable effects on lymphocytes or 96 h response. Josamycin had no effects on the model. Conclusions The therapeutic dosage of erythromycin significantly suppressed acute neutrophil influx into the lung, intradermal Arthus reaction and the expression of ICAM-1 in the lesions of experimental EAA. Erythromycin may be effective for treating subjects with acute EAA." @default.
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• W2006760925 date "1999-02-01" @default.
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• W2006760925 title "Effects of erythromycin on experimental extrinsic allergic alveolitis" @default.
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• W2006760925 doi "https://doi.org/10.1046/j.1365-2222.1999.00430.x" @default.
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