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- W2006779040 abstract "Biophysical signaling is required for both embryonic polarity and regenerative outgrowth. Exploiting endogenous ion transport for regenerative therapies will require direct regulation of membrane voltage. Here, we develop a pharmacological method to target ion transporters, uncovering a role for membrane voltage as a key regulator of anterior polarity in regenerating planaria. Utilizing the highly specific inhibitor, SCH-28080, our data reveal that H(+),K(+)-ATPase-mediated membrane depolarization is essential for anterior gene expression and brain induction. H(+),K(+)-ATPase-independent manipulation of membrane potential with ivermectin confirms that depolarization drives head formation, even at posterior-facing wounds. Using this chemical genetics approach, we demonstrate that membrane voltage controls head-versus-tail identity during planarian regeneration. Our data suggest well-characterized drugs (already approved for human use) might be exploited to control adult stem cell-driven pattern formation during the regeneration of complex structures." @default.
- W2006779040 created "2016-06-24" @default.
- W2006779040 creator A5045840183 @default.
- W2006779040 creator A5048756641 @default.
- W2006779040 creator A5078578076 @default.
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- W2006779040 date "2011-01-01" @default.
- W2006779040 modified "2023-10-17" @default.
- W2006779040 title "A Chemical Genetics Approach Reveals H,K-ATPase-Mediated Membrane Voltage Is Required for Planarian Head Regeneration" @default.
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- W2006779040 doi "https://doi.org/10.1016/j.chembiol.2010.11.012" @default.
- W2006779040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3278711" @default.
- W2006779040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21276941" @default.
- W2006779040 hasPublicationYear "2011" @default.
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